摘要
目的:探讨非酒精性脂肪肝(NAFLD)与冠心病急性冠脉综合征(ACS)发病的关系。方法:收集2006年1月至2013年12月因ACS住院的患者140例,将所有患者是否合并NAFLD分为NAFLD组(n=80)及非NAFLD组(n=60),通过血管超声结果比较两组颈动脉斑块检出率。并将ACS分为3个临床亚组不稳定型心绞痛(UA)、急性ST段抬高心肌梗塞(STEMI)、急性非ST段抬高心肌梗塞(NSTEMI),观察各亚组与NAFLD发病率有无差异性。比较NAFLD组和非NAFLD组甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)的水平有无差异性。结果:ACS合并NAFLD组颈动脉斑块检出率明显高于非NAFLD组(85%vs40%),两组比较差异有统计学意义(P<0.01);ACS 3个亚组NAFLD发病率与非NAFLD发病率差异无统计学意义(P>0.05);NAFLD组TG、TC、LDL-C水平明显高于非NAFLD组(P<0.05)。结论:NAFLD患者存在出现颈动脉斑块及高脂血症的高风险,是冠心病ACS的潜在危险因素,及时干预NAFLD患者可以在防治心血管疾病方面获益。
Objective： To study the correlation of non-alcoholic fatty liver disease （NAFLD） and acute coronary syndrome （ACS） pathogenesis. Methods： One hundred and forty cases of ACS with NAFLD hospitalized in our hospital from January 2006 to December 2013 were divided into NAFLI） group （n=80） and non NAFLD group （n=60）, the results were compared by vascular ultrasound detection rate of carotid plaque. ACS was divided into three clinical subgroups of unstable angina pectoris （UA）, acute ST segment elevation myocardial infarction （STEMI）, non ST segment elevation acute myocardial infarction （NSTEMI）. And the incidence of NAFLD was observed in each subgroup. Riglyceride （TG）, cholesterol （TC）, low density lipoprotein （LDL-C） levers have no difference in both NAFLD group and non NAFLI） group. Results： The detection rate of carotid plaque in ACS combined with NAFLD group was significantly higher than that in non NAFLD group （85% vs 40%）, there was significant difference between two groups （P〈 0.01 ）; there was no statistically significant in the three subgroups of ACS the incidence of NAFLD and non NAFLD incidence rate difference （P〉 0.05）; group NAFLD, TG, TC, LI）L-C level was significantly higher than that of non NAFLD group （P 〈 0.05）. Conclusion： NAFLD patients have high risk carotid atherosclerosis and hyperlipidemia appears, which is a potential risk factor for coronary heart disease ACS, timely intervention of NAFLD patients can be benefit in the prevention and treatment of cardiovascular diseases.
出处
《大理学院学报（综合版）》
CAS
2015年第8期18-21,共4页
Journal of Dali University
关键词
非酒精性脂肪肝
急性冠脉综合征
颈动脉斑块
non-alcoholic fatty liver disease
acute coronary syndrome coronary heart disease
carotid artery plaque
