摘要
慢性心力衰竭(chronic heart failure,CHF)是大多数心血管疾病的最终归宿,因具有高发病率、高病死率而引起人们的关注。CHF的标志是左心室进行性扩张、左室壁压力的增加,导致心肌耗氧量增加。根据拉普拉斯定律,运用一种组织工程学技术增加室壁厚度、减少心室腔直径,从而减少室壁压力、改善左室功能,本文总结归纳了这种组织工程技术在治疗CHF中的作用机制和Algisyl-LVR相关的试验结果。
Chronic heart failure （CHF） is the end result of various cardiovascular diseases. It has caused much concern because of its high morbidity and mortality. The hallmark of CHF is the progressive dilatation of the left ventricle, thinning of the left ventricular wall leading to increased wall stress and increased myocardial oxygen consumption. Applying Laplace＇s law,utilizes a tissue engineering strategy to increase wall thickness and reduce chamber volume, resulting in a decrease in wall stress and improved left ventricular function. The present review primarily focuses on the rationale for an tissue engineering approach for this treatment of CHF and experiment re- suits of the Algisyl-LVR program are presented treatment of heart failure.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2015年第8期805-807,共3页
Journal of Clinical Cardiology
基金
国家自然科学基金(No:81170133,81200088,81470387)
宜昌市科技研究与开发项目(No:A12301-01)
三峡大学研究生科研创新基金(2015CX098)
湖北省首届医学领军人才基金
