摘要
目的探讨Latexin(LXN)在食管鳞癌组织中的表达情况及临床价值。方法采用组织芯片和免疫组织化学技术检测183例食管鳞癌组织中的LXN蛋白表达,并分析其表达情况与临床病理参数(肿瘤大小、T分期、N分期、分化程度和TNM分期)及预后间的关系。结果 LXN在癌旁食管鳞状上皮中呈微弱表达,阳性表达率为100.0%,而在食管鳞癌组织中呈淡黄色或不表达,其阳性表达率为48.6%(89/183),低于癌旁组织(P<0.05);LXN阳性表达与肿瘤大小、T分期、N分期、组织分化及TNM分期有关。单因素生存分析表明LXN阳性表达者的中位总生存期长于LXN阴性表达者(P=0.001)。结论 LXN在食管鳞癌中表达下调,且与临床病理参数有关,在一定程度上反映了食管癌的不良预后。
Objective To investigate the clinical significance of Latexin（LXN） in esophageal squamous cell carcinoma（ ES-CC）. Methods In this study, 183 cases of ESCC tissues and para-carcinoma tissues were evaluated for LXN expression by tissue mi- croarray and immunohistochemistry. The relationship between the expression of LXN and clinical parameters （ tumor size, T staging, N stagings, differentiation and TNM staging） and prognosis were analyzed. Results The positive rate of LXN expression was 48. 6% in ESCC tissues, lower than 100. 0% in para-carcinoma tissues. A significant correlation was observed between the expression of LXN and tumor size, T staging, N staging, tumor differentiation and TNM staging. Patients with LXN positive expression had longer overall sur- vival than those without LXN expression. Conclusion LXN was down-regulated with the development and progression of ESCC and loss of LXN expression is associated with the poor prognosis of ESCC.
出处
《临床肿瘤学杂志》
CAS
2015年第7期607-610,共4页
Chinese Clinical Oncology
关键词
组织芯片
Latexin
食管鳞癌
Tissue Microarray
Latexin
Esophageal squamous cell carcinoma
