摘要
目的对比分析目前临床实践中序贯治疗高龄患者社区获得性肺炎（CAP）常用的氟喹诺酮类药物方案的疗效。方法收集2010年1月至2013年12月在我院收治的年龄≥65岁CAP患者130例,随机分为左氧氟沙星组和莫西沙星组,根据CAP的标准治疗方案分别给予左氧氟沙星静脉滴注500mg/d和莫西沙星静脉滴注400mg/d。静脉给药两天后若患者症状改善则改为口服相应药物序贯治疗,总疗程为7～14d。治疗期间,观察两种治疗方案的临床及细菌学效果,并评估其用药安全性。结果莫西沙星组治疗的总疗程短于左氧氟沙星组,并且莫西沙星组的治愈率和有效率均高于左氧氟沙星组,但两者发生不良反应风险相当。结论莫西沙星序贯治疗方案在疗效上优于左氧氟沙星序贯治疗方案,但左氧氟沙星的价格较便宜,临床工作中应综合各方面因素选择治疗方案。
Objective To analyze the efficacy of current clinical practice of sequential treatment of fluoroquinolones on elderly patients with community-acquired pneumonia （CAP）. Methods The 130 patients from with CAP ~65 years were divided into moxifloxacin group and levofloxacin group, which were treated with moxifloxacin injection 400mg/d or levofloxacin 500mg/d followed by according pills if their symptoms improved after 2 days, respectively. The total course was 7-14 days. The clinical and bacteriological results were observed and drug safety was assessed. Results The total course of treatment of moxifloxacin group was shorter than that of levofloxacin group. Moxifloxacin group cure rate and effective rate were higher than that of sequential treatment group. But both the risk of adverse reactions was equal. Conclusion Sequential treatment with moxifloxacin is better than sequential treatment with levofloxacin. But levofloxacin is cheaper than moxifloxacin.
出处
《西部医学》
2015年第8期1230-1232,共3页
Medical Journal of West China
基金
四川省卫生厅科研课题(090412)
关键词
社区获得性肺炎
老年
序贯治疗
莫西沙星
左氧氟沙星
Community-acquired pneumonial Elderly patients
Sequential therapy, Moxi{loxaein~ Levo{loxacin
