摘要
根据原白头翁素的结构是带γ-亚甲基的共轭不饱和五元环内酯设计合成了五种辅助化合物:α-当归内酯、β-当归内酯、α-亚甲基-γ-丁内酯、β-亚甲基-γ-丁内酯γ-亚甲基-γ-丁内酯,以研究原白头翁素的结构与其生物活性的关系。通过五种辅助化合物和原白头翁素的生物活性实验,得出了原白头翁素的抗菌生物活性中心为连在五元环内酯上的亚甲基(甲叉,methylene CH_2=)的结论。
Based on the structure of Protoanemonin-five member cyclical unsaturated lactone with γ-methy-lene, five complementary compounds are designed and synthesized α-angelolactone、β-angelolactone、α-methylene-γ-butyrolactone、β-methylene-γ-butyrolactpne、γ-methylene-γbutyrolactone. to study the relations between the structure and bioactivity of protoanemonin. A conclusion is drawn as that the antibiotic activity centre of protoanemonin is the methylene (CH_2=) which lies in the five member cyclical lactone.
基金
国家自然科学基金
关键词
原白头翁素
生物活性
抗菌活性
antibiotic active substance, protoanemonin, synthesis, bioactive center.
