摘要
由于新生儿处于从宫内环境向宫外环境的过渡期，内环境变化大，且肾脏的结构、功能发育不成熟，与成人相比，肾脏储备能力低下。在正常情况下，新生儿肾脏的成熟能与生长发育相适应，维持内环境于一个相对平衡状态，但在各病理因素影响下，却极易出现急性肾损伤，不仅会造成水电解质紊乱和酸碱失衡，增加短期的不良预后，还会影响生后肾脏结构功能的进一步成熟，甚而增加远期慢性肾脏病的风险。
Once umbilical cord ligation,neonatal kidney will be responsible for maintaining the whole-body homeostasis and the excretory requirements of the newborn. Meanwhile,there is a significant physiologic changes that occurs during the transition from intrauterine to extrauterine life. Neonatal renal reserve is less than adults,for the structure and function of the kidney still undergo a maturation process. Under the normal condi-tion,the adaptive changes of the renal function,with neonatal growth and development,can keep a delicate bal-ance of the internal environment. If they are exposed to a variety of external stressors,their immature kidney is especially vulnerable,which will not only cause fluid,electrolyte and acid-base imbalances and the adverse prog-nosis,but effect kidney structure and function further mature and increase the long-term risk of chronic kidney disease as well.
出处
《国际儿科学杂志》
2015年第4期405-408,共4页
International Journal of Pediatrics
关键词
新生儿
早产儿
急性肾损伤
慢性肾脏病
Neonate
Premature
Acute kidney injury
Chronic kidney disease
