摘要
目的了解郑州地区泌尿生殖道支原体感染及耐药状况。方法收集2012年7月至2013年6月于我院进行泌尿生殖道支原体检测的患者13 331例,根据患者年龄分为≤18岁组、19-30岁组、31-40岁组、41-50岁组、51-60岁组以及≥61岁组,检测所有患者的解脲脲原体（Ureaplasma urealyticum,Uu）、人型支原体（Mycoplasma hominis,Mh）以及混合感染（Uu＋Mh）的情况,并对不同类型支原体的耐药情况进行分析。结果 13 331份标本中,支原体的总检出率为50.57%（6741/13 331）,其中Uu的构成比最高,为85.85%（5787/6741）。Uu及Uu＋Mh的检出率在不同年龄段的差异均有统计学意义（P均〈0.05）,其中Uu阳性率最高的为19-30岁组,阳性率为45.10%;Mh阳性率最高的为≥61岁组,阳性率为1.52%;Uu＋Mh阳性率最高的为51-60岁组,阳性率为9.31%。药敏试验结果显示,Uu的耐药情况较Mh感染及混合感染轻。所有类型的支原体对四环素类药物的敏感率均大于90%,Uu对红霉素类药物较敏感,而Mh对除交沙霉素外的其他红霉素类药物的耐药率均较高;Uu及Mh对喹诺酮类药物有不同程度的耐药,需进行药敏筛选。结论郑州地区泌尿生殖道支原体总检出率为50.57%,Uu为泌尿生殖道支原体感染的主要病原体。Uu感染主要分布在19-50岁年龄段,混合感染主要分布在41-60岁年龄段。四环素类抗生素可作为本地区治疗泌尿生殖道支原体感染的首选用药,为控制耐药情况应同时结合药敏结果用药。
Objective To investigate the infection and drug resistance of Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh） in Zhengzhou. Methods 13 331 patients were collected in our hospital from July 2012 to June 2013 for Uu and Mh detection. All patients were divided into ≤ 18 age group, 19-30age group, 31-40 age group, 41-50 age group, 51-60 age group and ≥ 61 age group. Uu, Mh and Uu＋Mh of all patients were detected, and drug resistance were analyzed. Results The Mycoplasma infection rate in 13331 samples was 50.57%（6741 / 13 331）, and the highest constituent ratio was Uu（85.85%, 5787 / 6741）. The difference of Uu infection rates and the mixed infection rates among different ages groups were significant（Pall〈0.05）, while the difference of Mh infection rates among different ages groups was not significant. The highest positive rate of Uu was 19 -30 age group（45.10%）, the highest positive rate of Mh was ≥ 61 age group（1.52%）, and the highest rate of Uu ＋Mh was 51 -60 age group（9.31%）. Compared with Mh and mixed infection, drug resistance of Uu was less serious. Tetracyclines antibiotic sensitive rate for Mycoplasma were more than 90%. Excepted josamycin, erythromycins were sensitive for Uu but not for Mh. Quinolones were resistant in varying degrees for Uu and Mh and antibiotic screening test should be done. Conclusion The infection rate of Mycoplasma in the people who likely had urogenital tract infection is 50.57% in Zhengzhou. Uu infection is distributed mainly from 19-50 age and the mixed infection is distributed mainly from 41-60 age.For treatment, we can use Tetracyclines as the first choice drug in this area. At the same time, antibiotic screening test also should be done for drug resistance control.
出处
《实用检验医师杂志》
2015年第2期100-103,共4页
Chinese Journal of Clinical Pathologist
基金
临床检验诊断学河南省科技厅重点科研团队项目(B20140269)
关键词
解脲脲原体
人型支原体
感染率
耐药性
泌尿生殖道
Ureaplasma urealyticum
Mycoplasma hominis
Infection rate
Drug resistance
Urogenital tract
