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癌变组织中AKT及Her2的表达与乳腺癌的相关性分析

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摘要 目的探讨蛋白激酶B(AKT)及人表皮生长因子受体2(Her2)在乳腺癌组织中的表达情况及与乳腺癌分期的相关性。方法将150例非乳腺癌的乳腺疾病患者作为对照组,将150例乳腺癌患者作为研究组。对比2组乳腺组织中AKT及Her2的阳性表达率。并根据癌组织分级将研究组分为Ⅰ级61例、Ⅱ级51例及Ⅲ级38例,对比三组间AKT及Her2阳性表达率与癌组织分级的相关性。结果研究组AKT及Her2阳性表达率明显高于对照组(P<0.05);Ⅱ级组及Ⅲ级组中AKT及Her2阳性表达率明显高于Ⅰ级组(P<0.05),且AKT及Her2阳性表达率与癌组织分级间有着显著的正向直线相关性(r=9.129,11.281,P<0.05)。结论 AKT及Her2的阳性表达率在乳腺癌组织中有效明显的升高,且与癌组织分级有着显著的相关性。
出处 《临床合理用药杂志》 2015年第19期155-156,共2页 Chinese Journal of Clinical Rational Drug Use
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