摘要
目的:通过检测肝素结合性表皮生长因子(HB-EGF)在多囊卵巢综合征(PCOS)患者血清和卵泡液中的表达量,探讨PCOS发病的可能机制。方法:选择60例因PCOS实施体外受精-胚胎移植(IVF-ET)术患者为PCOS组;同期卵巢反应正常,因输卵管阻塞接受IVF治疗的患者60例作为对照组,收集两组采卵日的血清及卵泡液,采用酶联免疫吸附试验(ELISA)检测血清和卵泡液中HB-EGF的表达量。结果:PCOS组患者血清及卵泡液中HB-EGF表达量均显著高于对照组(P<0.01);PCOS组和对照组血清HB-EGF水平均明显高于卵泡液,且呈正相关(r=0.85,P<0.01;r=0.87,P<0.01)。结论:PCOS患者存在高HB-EGF血症,卵泡液中HB-EGF升高可能受血清中HB-EGF影响,HB-EGF可能与PCOS的发生机制有关。
Objective： To detect the correlation between the heparin-binding epidermal growth factor （HB- EGF） level in serum and follicular fluid and polycystic ovary syndrome（PCOS） ,and the possible role of HB-EGF in the pathogenesis of PCOS. Methods ：The samples of serum and follicular fluid were collected from 60 patients who underwent in vitro fertilization and embryo transfer（IVF-ET） due to PCOS（ PCOS group）and 60 women with regular ovulation who underwent IVF due to fallopian tube factors（control group）. The levels of HB-EGF were detected by ELISA. Results：The levels of HB-EGF in serum, follicular fluid in PCOS group were both higher than those in the control group, respectively（ P 〈 0.01 ）. In both two groups,the serum HB-EGF levels were higher than and positively correlated with the follicular fluid levels（ r =0. 85, P 〈 0.01 ;r = 0.87, P 〈0. 01 ）. Conclusions：Higher serum HB-EGF was correlated with PCOS. HB-EGF may participate in the pathogenesis of PCOS,and the increase of follicular fluid HB-EGF may be partially correlated with the serum HB-EGF.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2015年第7期508-511,共4页
Journal of Practical Obstetrics and Gynecology
基金
宁夏医科大学科学基金资助(编号:XQ201323)
关键词
肝素结合性表皮生长因子
多囊卵巢综合征
血清
卵泡液
Heparin-binding epidermal growth factor
Polycystic ovary syndrome
Serum
Follicular fluid
