摘要
目的探讨汉族、维吾尔族及哈萨克族甲状腺结节与代谢综合征(MS)的相关性。方法选取2013年新疆医科大学第一附属医院体检中心体检者5 870例为研究对象,其中汉族4 643例,维吾尔族996例,哈萨克族231例。对体检者进行人体指标测量、血生化指标检测和甲状腺超声检测。结果汉族、维吾尔族和哈萨克族体检者性别、年龄、身高、体质量、体质指数(BMI)、收缩压、舒张压、三酰甘油(TG)、高密度脂蛋白胆固醇(HDLC)、空腹血糖(FPG)比较,差异均有统计学意义(P<0.05)。3个民族体检者甲状腺结节检出率分别为28.0%(1 299/4 643)、30.9%(308/996)、39.8%(92/231),差异有统计学意义(χ2=17.309,P<0.001)。3个民族体检者MS检出率分别为16.3%(756/4 643)、23.5%(234/996)、22.9%(53/231),差异有统计学意义(χ2=33.596,P<0.001)。汉族体检者中,MS、FPG、血压与甲状腺结节具有关联性(χ2=14.830、19.625、59.757,P<0.05),且随MS相关组分的增加,患甲状腺结节的风险有增高的趋势(χ2趋势=17.195,P<0.05);维吾尔族体检者中,MS、BMI、FPG、血压与甲状腺结节具有关联性(χ2=8.136、14.416、7.707、14.218,P<0.05),且随MS相关组分的增加,患甲状腺结节的风险有增高的趋势(χ2趋势=15.480,P<0.05);哈萨克族体检者中,血压与甲状腺结节具有关联性(χ2=10.745,P<0.05),甲状腺结节患病风险与MS组分无趋势性关系(P=0.612)。Logistic回归分析显示,性别〔OR=3.061,95%CI(2.622,3.573)〕、年龄〔OR=1.046,95%CI(1.040,1.052)〕、血压〔OR=1.217,95%CI(1.036,1.431)〕是汉族患甲状腺结节的危险因素,性别〔OR=2.861,95%CI(2.020,4.053)〕、年龄〔OR=1.077,95%CI(1.061,1.093)〕、BMI〔OR=1.550,95%CI(1.064,2.357)〕是维吾尔族患甲状腺结节的危险因素,性别〔OR=4.401,95%CI(2.068,9.366)〕、年龄〔OR=1.067,95%CI(1.037,1.098)〕、血压〔OR=2.104,95%CI(1.081,4.091)〕是哈萨克族患甲状腺结节的危险因素。结论甲状腺结节与MS及其组分密切相关,不同民族间甲状腺结节患病危险因素不同,应针对不同民族人群甲状腺结节的危险因素采取综合有效的防治措施。
Objective To explore the relationship of thyroid nodules（TN） and metabolic syndrome（MS） among Han,Uygur and Kazakh.Methods A cross-sectional study was performed in 5 870 physical examiners（4 643 Han,996 Uygur,231 Kazakh） in the physical examination center of First Teaching Hospital of Xinjiang Medical University in 2013.The subjects had measuring of human indicator,blood biochemical parameters and thyroid ultrasound.Results There was significant difference in gender,age,height,weight,BMI,SBP,DBP,TG,HDL-C,FPG among Han,Uygur,Kazakh（P 0.05）.The TN detection rate was 28.0%（1 299/4 643） in Han,30.9%（308/996） in Uygur,39.8%（92/231） in Kazakh,the difference was significant（χ2= 17.309,P 0.001）; MS detection rate was 16.3%（756/4 643） in Han,23.5%（234/996） in Uygur,22.9%（53/231） in Kazakh,the difference was significant（χ2= 33.596,P 0.001）.In Han subjects,MS,FPG,blood pressure（BP） were associated with TN（χ2= 14.830,19.625,59.757,P = 0.05）,and TN risks increased with the increase of MS component numbers（χ2trend= 17.195,P = 0.05）; in Uygur subjects,MS,BMI,FPG,BP were related to TN（χ2= 8.136,14.416,7.707,14.218,P = 0.05）,and TN risks increased with the increase of MS component numbers（χ2trend= 15.480,P = 0.05）; in Kazakh subjects,BP related to TN（χ2= 10.745,P = 0.05）,there was no tendency between TN risks and MS component numbers（P = 0.612）.Logistic regression analysis showed that gender〔OR = 3.061,95% CI（2.622,3.573） 〕,age 〔OR = 1.046,95% CI（1.040,1.052） 〕,BP 〔OR = 1.217,95% CI（1.036,1.431） 〕were risk factors of TN in Han; gender 〔OR = 2.861,95% CI（2.020,4.053） 〕,age 〔OR = 1.077,95% CI（1.061,1.093） 〕,BMI 〔OR = 1.550,95% CI（1.064,2.357） 〕were risk factors of TN in Uygurs; gender〔OR =4.401,95% CI（2.068,9.366） 〕,age 〔OR = 1.067,95% CI（1.037,1.098） 〕,BP 〔OR = 2.104,95% CI（1.081,4.091） 〕were risk factors of TN in Kazakh.Conclusion TN is closely related to MS and its component numbers.Different nationalities have different TN risk factors.Comprehensive,effective measures should be taken to control TN risk factors based on ethnic differences.
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第20期2393-2397,共5页
Chinese General Practice
基金
新疆维吾尔自治区科技支疆项目(2013911113)
关键词
甲状腺结节
代谢综合征X
汉族
维吾尔族
哈萨克族
Thyroid nodule
Metabolic syndrome X
Han nationality
Uygur nationality
Kazakh nationality
