摘要
目的：观察儿童牵牛花综合征（MGS）患眼荧光素眼底血管造影（FFA）特征。方法临床确诊为 MGS 的14例患儿14只眼纳入研究。其中,男性、女性各7例7只眼。合并永存原始玻璃体增生症4只眼,占28.57%；合并视网膜脱离4只眼,占28.57%,均未见视网膜裂孔；合并视盘旁视网膜下黄白色渗出1只眼,占7.14%。所有患儿应用第三代广角数码视网膜成像仪行眼底及 FFA 检查。测量患眼及对侧健康眼视盘纵轴、横轴长度。记录臂-视网膜循环时间（A-RCT）,观察患眼及对侧健康眼视盘边缘显影血管数量、视网膜血管形态及走形、周边部视网膜无灌注区等异常情况。选择同期行 FFA 检查诊断为眼底正常的16名儿童作为对照组。对比分析患眼与对照组受检眼 A-RCT 的情况。结果患眼视盘纵轴长度是对侧健康眼的1.58~3.31倍,平均（2.56±0.58）倍；视盘横轴长度是对侧健康眼的1.18~3.70倍,平均（2.73±0.60）倍。FFA 检查发现,患眼 A-RCT 为9.83~16.56 s,平均 A-RCT 为（13.25±4.10）s。对照组受检眼 A-RCT 为5.83~13.44 s,平均 A-RCT 为（9.34±2.20）s。患眼 A-RCT 较对照组受检眼明显延迟。早期患眼视盘呈弱荧光,视盘周围色素遮蔽呈弱荧光,其外侧不规则视网膜脉络膜萎缩区呈强荧光环；晚期视盘组织着染呈强荧光。患眼、对侧健康眼视盘边缘处显影血管平均数分别为（30.27＆#177;4.86）、（15.83±1.95）支。患眼视盘边缘处显影血管数明显多于对侧健康眼。所有患眼均存在周边部视网膜无灌注区。结论MGS 患眼 FFA 特征为视盘扩大,视盘边缘显影血管数量增多,A-RCT 延迟及周边部视网膜无灌注区。
Objective To observe the fundus fluorescein angiography （FFA） manifestations of pediatric morning glory syndrome （MGS）patients.Methods Fourteen eyes diagnosed as MGS of 14 patients were studied.Among the 14 cases,there were 7 male and 7 female patients.At the time of FFA, the mean age of the patients was （38.75＆#177;33.91）months old,ranging from 5.5 to 128.0 months.Among the 14 eyes,four （28.57%）were associated with persistent hyperplastic primary vitreous;four （28.57%） were associated with retinal detachment with no retinal breaks,and one （7.14%）was associated with peripapillary subretinal exudation.All patients underwent peripapillary laser photocoagulation under general anesthesia first and then FFA with the third generation of wide-angle digital retinal imaging system.The arm-retinal circulation time （A-RCT）,numbers of blood vessels on the edges of optic disc of the MGS eyes and the contralateral healthy eyes, retinal vascular morphology, the peripheral avascular area, neovascularization,retinal detachment and other abnormalities were documented.The horizontal and vertical diameters of the optic disc of the affected eyes and the contralateral healthy eyes were measured.To compare the A-RCT,1 6 children with normal FFA were selected as control group.Results The diameters of the vertical and horizontal axis of the affected eyes were as （2.56 ± 0.58 ）and （2.73 ±0.60 ）times of the contralateral healthy eyes respectively.The average A-RCT of the affected eyes and eyes of the control group were （13.25±4.10）and （9.34±2.20）s respectively.The affected eyes had significantly prolonged A-RCT.At early stage,the optic disc and peripapillary areas showed hypo-fluorescence,while the irregular retinochoroidal atrophy area outside of the optic disk manifested as hyper-fluorescence ring.At late stage, optic disc showed hyper-fluorescence.Numbers of blood vessels on the edge of the optic disc of the affected eyes and contralateral healthy eyes were 30.27±4.86 and 1 5.83±1.95 respectively,the affected eyes had much more vessels than the contralateral healthy eyes.All affected eyes had peripheral retinal non-perfusion areas.Conclusion FFA examination showed prolonged A-RCT and peripheral retinal non-perfusion areas in the affected MGS eyes.
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2015年第4期355-358,共4页
Chinese Journal of Ocular Fundus Diseases
关键词
视神经疾病/诊断
视盘/畸形
荧光素血管造影术
Optic nerve diseases/ diagnosis
Optic disk/abnormalities
Fluorescein angiography
