摘要
目的研究麝香保心丸对急性心肌梗死(AMI)患者QT间期离散度(QTd)的影响。方法 80例AMI患者随机分为治疗组和对照组,每组40例。对照组采用常规药物治疗,治疗组在对照组治疗基础上加用麝香保心丸治疗。在治疗前和治疗4周后分别测量QTd及校正QT间期离散度(QTcd),并观察治疗前、后室性心律失常及心源性猝死例数。结果两组治疗后QTd、QTcd与治疗前比较均显著减小(P<0.05);两组治疗后各指标比较,治疗组优于对照组,差异有统计学意义(P<0.01),治疗后心源性猝死及室性心律失常的发生率对照组高于治疗组,差异有统计学意义(P<0.05)。结论麝香保心丸可以明显缩短QTd、QTcd,减少室性心律失常及心源性猝死发生率,而从电生理角度来评析麝香保心丸可作为治疗急性心肌梗死的基础用药之一。
Objective To research influence of Shexiangbaoxin pills on QT interval dispersion （QTd） in acute myocardial infarction （AMI） patients. Methods A total of 80 AMI patients were randomly divided into treatment group and control group, with 40 cases in each group. The control group received conventional drug for treatment, and the treatment group received additional Shexiangbaoxin pills. Their QTd and heart rate-corrected QT interval dispersion （QTcd） were detected before treatment and after 4 weeks of treatment. Observations were made on ventricular arrhythmias and sudden cardiac death number before and after treatment. Results Both groups had remarkable decrease in QTd and QTcd after treatment, compared with those before treatment （P〈0.05）. After treatment, the treatment group had better indexes than the control group, and their difference had statistical significance （P〈0.01）. The control group had higher incidences of ventricular arrhythmias and sudden cardiac death than the treatment group after treatment, and their difference had statistical significance （P〈0.05）. Conclusion Shexiangbaoxin pills can obviously reduce QTd, QTcd, and incidences of ventricular arrhythmias and sudden cardiac death. It is one of the basic medicines for acute myocardial infarction in the aspect of electrophysiology.
出处
《中国现代药物应用》
2015年第15期37-39,共3页
Chinese Journal of Modern Drug Application
关键词
急性心肌梗死
麝香保心丸
QT间期离散度
Acute myocardial infarction
Shexiangbaoxin pills
QT interval dispersion
