摘要
熊果酸是广泛存在于天然植物中的一种三萜类化合物。研究表明熊果酸在脑炎、支气管哮喘、肠炎、类风湿关节炎、神经损伤等炎症和氧化损伤相关的疾病中，通过抑制核因子κB、激活过氧化物酶体增殖物激活受体γ、抑制丝裂原活化蛋白激酶信号通路、增加抗氧化物酶活性、减少脂质过氧化等机制发挥重要的抗炎和抗氧化作用。
Ursolic acid is a triterpenoids presented in natural plant widely. Studies have shown that ursolic acid plays an important anti-inflammatory and antioxidant effects through inhibiting nuclear factor-κB, activation of peroxisome proliferator-activated receptor γ,inhibition of mitogen-activated protein kinase signaling pathway, increasing antioxidant enzyme activity, reducing lipid peroxidation and other mechanisms in many diseases associated with inflammation and oxidative damage such as encephalitis, bronchial asthma, inflammatory bowel disease, rheumatoid arthritis, nerve damage, etc.
出处
《国际呼吸杂志》
2015年第13期1022-1025,共4页
International Journal of Respiration
关键词
熊果酸
抗炎
抗氧化
Ursolic acid
Anti-inflammatory
Antioxidant
