摘要
目的了解以肝功能异常作为首发症状的系统性红斑狼疮(SLE)的临床特点及如何避免误诊。方法选取我院以肝功能异常为首发症状住院的SLE患者15例,对每位患者进行SLE疾病活动指数(SLE-DAI)评分,并检测每位患者的肝功能,凝血酶原活动度,自身抗体谱及超声检查等。结果以肝功能异常为首发症状的SLE易被误诊,本研究入选的15例患者中只有7例(46.6%)在肝功能异常出现1周内确诊SLE,有8例(53.3%)患者就诊2周至4月后才确诊,其中最长1例患者肝损伤出现8年后方确诊其肝损伤为SLE所致。结论 SLE导致肝损伤并不少见,故需对此类患者加以鉴别。
Objective To study the clinical characteristics of the patients with abnormal liver function as the first symptom of systemic lupus erythematosus（SLE）.Methods Fifteen patients in our hospital with initial presentation of lupus-related hepatitis or cirrhosis were included in this study.For each eligible patient,the SLE disease activity index（SLE-DAI）score,clinical and laboratory data were collected,including clinical manifestation,hepatic function,autoantibody and type-B ultrasonic check.Results The diagnosis of SLE could be delayed or wrongly diagnosed when hepatic abnormalities were the prominent feature.Among the whole 15 admitted patients,only 7cases（46.6%）were identified as SLE within a week after the presentation of abnormal liver function,while 8cases（53.3%）were not diagnosed as SLE until more than 2 weeks to 4 months after the presentation of abnormal liver function,and even,1patient with abnormal liver function appeared 8years before diagnosis of the liver injury induced by SLE.Conclusion Liver injury cause by SLE is not uncommon,and can easily to be misdiagnosed,which should pay more attention.
出处
《临床荟萃》
CAS
2015年第7期806-810,共5页
Clinical Focus
基金
北京市教育委员会科技计划项目(KM201310025024)
关键词
红斑狼疮
系统性
肝损伤
临床特点
激素治疗
lupus erythematosus
systemic
hepatic abnormality
clinical characteristics
glucocorticoid treatment
