摘要
目的观察中药养阴益胃汤对慢性萎缩性胃炎模型大鼠的治疗作用,并探讨其作用机制。方法以大鼠饮用0.1%氨水建立慢性萎缩性胃炎(CAG)模型,养阴益胃汤治疗90 d后观察胃粘膜炎症情况,检测大鼠胃粘膜血流量(GMBF)、胃粘膜超氧化物歧化酶(SOD)活力、谷胱甘肽(GSH-PX)活力及丙二醛(MDA)含量。结果养阴益胃汤高、中剂量组大鼠胃黏膜组织学接近正常组。与模型组相比,养阴益胃汤各剂量组大鼠胃黏膜SOD、GSH-PX明显升高,MDA显著降低,GMBF显著增高。结论养阴益胃汤对慢性萎缩性胃炎模型大鼠胃粘膜有良好的治疗作用,能改善和逆转实验性萎缩性胃炎大鼠胃粘膜萎缩。其机制可能与其增加胃粘膜血流量、增强胃粘膜屏障功能、抗自由基损伤等有关。
Objective To study the function of Yangyin Yiwei decoction on Treating Chronic Atrophic Gastritis（CAG） model rats and investigate its mechanism. Methods Made rats CAG model with 0.1% ammonia water. After 90 days treated, observe the gastric mucosa inf Iammation and gastric atrophy level, detect the change of glutathione（ GSH- PX）, superoxide dismutas（SOD）, malonyl dialdehyd（MDA）contents in gastric mucosa. Measuring Gastric mucosal blood flow（GMBF）. Results There is no significant difference of gastric mucosal histology features among the Yangyin Yiwei decoction high- dosage, medium- dosage groups and the normal control group. Compared to model group,Yangyin Yiwei Decoction has made a significant increase of SOD, GSH- PX in the CAG rats,and can make the levels of MDA decrease significantly, and can make a significant increase of GMBF（P〈0.05,P〈0.01）. Conclusion The Chinese drug Yangyin Yiwei decoction has good curative effect to chronic atrophic gastritic model rats,and it can also improve and reverse the gastric atrophy of experimental atrophic gastritis of rats. Its mechanism maybe related with improving blood circulation of gastric mucosa, strengthening gastric mucosal protective screen and resisting the free radical impairment and so on.
出处
《现代中药研究与实践》
CAS
2015年第3期28-30,共3页
Research and Practice on Chinese Medicines
基金
河北省高等学校科学技术研究项目(Z 2013006)
关键词
养阴益胃汤
慢性萎缩性胃炎
大鼠
Yangyin Yiwei decoction
chronic atrophic gastritis
rats
