摘要
本文报道国产头孢三嗪正常人药代动力学及对胎盘等组织体液穿透性的研究结果。给8名健康志愿者肌注、静注和静滴本品1克后,血药峰浓度分别为124.6mg/L、182.9mg/L和156.3mg/L。肌注后达峰浓度时间(tmax)为1.9小时。三种途径给药后的消除半衰期均为8小时左右。肌注、静注和静滴本品1克后尿药峰浓度分别为751.1mg/L、1063.3mg/L和827.5mg/L,给药后48小时尿中排出给药量的40％左右。单次静注本品1克后胎盘、脐血、脐带组织和羊水中药物浓度分别为1.86μg/g、26mg/L、0.87μg/g和3.2mg/L,胆汁中浓度达1000mg/L左右,为同期血浓度的30倍,胆囊壁组织中浓度为31.2μg/g。
The pharmacological study of ceftriaxone was undertaken.The clincal pharmacokinetic studies of ceftriaxone were carried out in 8 normal volunteers. The peak serum concentrations after im, iv injection and iv drip of ceftriaxone 1g were 124.6, 182.9 and 156.3 mg/L respectvely. Aftier given intramuscularly, the time to peak concentration (tmax) was 1.9h. The elimination half life was about 8h for each adnunstraton. Around 40% of the dose was excreted in the urinr within 48h. After a dose of 1g ceftriaxone given intramuocularly, intravenouly and through IV drip, the mean peak concentrations in the urine were 751.1, 1063.3 and 823.5mg/L respectively and remained above 100mg/L witihin 24h.
After given 1g ceftriaxone intravenously,the mean concentrations in the placents, blood of umbilical cord, umbilical cord tissue and amniotic fluid were 1.86μg/g, 26mg/L,0.87μg/g and 3.2mg/L respectively and the mean concentration in the bile was 100omg/L which was about 30 times of that in the serum, in the gallbladder wall the concentration was 31.2μg/h.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1991年第5期339-343,共5页
Chinese Journal of Antibiotics
关键词
头孢三嗪
药代动力学
组织体液
Ceftriaxone
Pharmacokmetics
Tissue distribuion
