摘要
本文报告头孢唑肟治疗72例感染性疾病的临床和实验研究。重症和难治性感染57例,临床治愈率为74％,总有效率为89.5％,细菌总清除率为82.1％。体外敏感度试验和血清杀菌试验均显示对多数致病菌的高度敏感性。头孢唑肟治疗淋球菌感染15例,临床有效率100％。部分经治疗患者的体液药物浓度测定麦明,头孢唑肟的组织渗透性较好,对多种细菌感染疗效满意。毒副作用轻,而主要是由于大剂量或长疗程所致。
The results of the treatment by ceftizoxime of 72 patients with various bacterial infections are reported.Fifty-seven of the 72 patients had severe infections, including 15 cases of respiratory infection, 15 obsteric and gynecological, 17 biliary tract and intra-abdominal infections as well as 10 patients -with septicemia, meningitis and others.Response of the therapy by ceftizoxime was excellent in 74.4% of patients and the overall response rate was 89.5%. The bacterial eradication rate was 82.1%. According to the results of in-vitro susceptibility test and serum bactericidal activity study,ceftizoxime was proved highly active against Enterobacte-riaceae, but poorly active against Ps. aeruginosa and Strep. faecalis.Fifteen patients with gonorrhea were also treated by ceftizoxime. The clinical response rate was 100 %.Measurement of body fluid concentration of ceftizoxime showed satisfactory tissue penetration. In the pleural and peritoneal fluid, bile and CSF, the peak concentrations were 7.22, 10.86, 43.41 and 7.40mg/L respectively. Clinically significant side effects were slight and may be related to large doses given for prolonged period.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1991年第4期287-293,共7页
Chinese Journal of Antibiotics
关键词
头孢唑肟
重症
淋球菌
感染
Ceftizosime
Severe infectious
Gonorrhea
