摘要
目的：探讨单唾液酸四己糖神经节苷脂（GM1）联合康复疗法治疗老年人脑梗死的临床疗效及对患者运动功能和日常生活能力的影响。方法将110例老年脑梗死患者采用随机数字表法分为两组，每组55例，均采取常规综合治疗，另外对照组在此基础上加用胞磷胆碱静脉滴注，观察组在此基础上加用 GM1联合康复治疗。观察并比较两组临床治疗效果及对患者运动功能和日常生活能力的影响。结果观察组总有效率为90．91％，显著高于对照组的76．36％（χ2＝10．33，P ＜0．05）；两组治疗后 Bathel 指数和 FMA 积分均较治疗前显著增加，差异均有统计学意义（t ＝7．11、9．83、8．66、10．27，均 P ＜0．05）；观察组治疗后 Bathel 指数和FMA 积分分别为（60．79±5．64）和（64．34±7．83）分，显著高于对照组（t ＝8．89、9．45，P ＜0．05）。结论GM1联合康复治疗老年人脑梗死的临床疗效显著，可有效改善患者运动功能障碍，提高其日常生活能力，具有较高的临床应用和推广价值。
Objective To investigate the efficacy and influence of motor function and activities of daily living of hexose ganglioside sialic four single（GM1）combined with rehabilitation in treatment of cerebral infarction（ACI）. Methods 110 patients with ACI were divided into the two groups in random number table,they were all treated with routine treatment,the patients of the control group（n =55）were given citicoline on the base of those addition,the patients of the observation group（n =55）were given hexose ganglioside sialic four single combined with rehabilitation. The efficacy and influence of motor function and activities of daily living of the two groups were observed and compared.Results The total efficiency of the observation group was 90.91%,which was significantly higher than 76.36% of the control group（χ2 =10.33,P 〈0.05）;The bathel index and the FMA points after treatment of the two groups were significant increased compared with before treatment,the difference was statistically significant（t =7.11, 9.83,8.66,10.27,all P 〈0.05）;The bathel index and the FMA points after treatment of the observation group were （60.79 ±5.64）and（64.34 ±7.83）,which were significantly higher than the control group（t =8.89,9.45,all P 〈0.05）.Conclusion Hexose ganglioside sialic four single combined with rehabilitation in treatment of cerebral infarc-tion had significant clinical effect,it can effectively improve motor dysfunction,improve their daily living skills,with a high clinical value and was worth to appliy.
出处
《中国基层医药》
CAS
2015年第13期2004-2006,共3页
Chinese Journal of Primary Medicine and Pharmacy
