摘要
目的:评价康派特医用胶对大鼠内脏创面止血后的安全性及其体内降解情况。方法:大鼠随机分为空白对照组,手术对照组和手术涂胶组,给胶组分别给予8μL或40μL康派特医用胶。术后动物进行临床症状观察,体重、摄食量测定,血常规、血清生化学、脏器重量和组织病理学检查。结果:各项指标均未见与康派特医用胶相关毒性反应;6个月组织病理学检查可见胶体被纤维结缔组织逐渐分割,多核巨细胞和炎症细胞参与异物降解。结论本实验条件下,未见康派特医用胶对大鼠机体有毒性作用,胶体在大鼠体内6个月开始降解。
Objective： To evaluate the safety of the visceral wound surface hemostasis in ratand degradation of Compontmedical adhesive in vivo.Methods： The rats were randomly divided into blank control group,the operation control group and the medical adhesive operation group.Rats in medical adhesive operation group were treated with 8 or 40μL medical adhesive.Clinical observations,body weight,food intake,blood routine,serum biochemical,organ weight and histopathological examination were performed on Postoperative animals.Results： No toxic effect was observed in all indexes related with Compont medical adhesive.Histopathological examination after administration for 6 months showed the colloid was gradually divided by fibrous connective tissue,and the degradation of foreign matter is participated by multinucleated giant cells and inflammatory cells.Conclusions： The Compontmedical adhesive were no toxic effect on the body of rats under the experimental conditions,and began to degrade in rats after 6 months.
出处
《医疗装备》
2015年第7期21-29,共9页
Medical Equipment
