摘要
为了研究冰片对反式白藜芦醇（resveratrol，Res）药代动力学的影响，将雄性sD大鼠分为灌胃给药和尾静脉注射给药两大组，灌胃给药组和尾静脉注射给药组均包括反式白藜芦醇（30mg／kg）单用组，反式白藜芦醇与低、中、高剂量冰片（50、100和200mg／kg）合用组．大鼠给药后不同时间点Res的血药浓度用高效液相色谱法测定，并用DAS3．0软件处理计算Res药动学参数．结果表明，不管是灌胃给药，还是静脉注射给药，冰片对反式白藜芦醇大鼠体内药动学均有明显影响．尾静脉注射给药中，单用Res对照组的药一时曲线下面积AUC0-∞为（127．04±29．84）mg／（L·min），血浆药物总清除率观。为（O．088±0．029）L／（min·kg）．低、中剂量冰片对Res的药代动力学无显著影响，高剂量冰片使血浆中Res的AUC0-∞，增大了73．6％，c厶降低了42．1％，且与对照组相比差异具有统计学意义（P〈0．05）．表明高剂量冰片可促进Res的吸收，降低Res的体内清除．
To study the effect of borneol on the pharmacokinetics of trans-resveratrol （Res）, male SD rats were divided into oral and intravenous administration groups including Res （30 mg/kg）used alone and combined with different doses（50,100 and 200 mg/kg）of borneol.After the drug administration, the blood concentration of Res was measured by high performance liquid chromatography, and the pharmacokinetic parameters were calculated by DAS3.0 software.The results showed that borneo1 significantly influenced the pharmacokinetics of Res following both oral and intravenous administration of Res.Compared with the intravenous administration of Res alone, low- and medium- dose of borneol had no significant effect on the pharmacokinetics of Res, while high-dose of borneol significantly increased the plasma concentration-time curve area （AUC0-∞）by 73.6%, decreasesd the total plasma drug clearance rate （CLx）by 42.1% （P 〈0.05）.The results indicated that high-dose of borneo1 could significantly accelerate the absorption and slow down the drug clearance of Res in rat in vivo.
出处
《湖北大学学报（自然科学版）》
CAS
2015年第4期316-321,共6页
Journal of Hubei University：Natural Science
基金
湖北省自然科学基金重点项目(2013CFA067)
湖北大学国家级大学生创新创业训练计划项目(201410512001)资助
