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γ干扰素释放试验诊断高危患者肺结核价值研究 被引量:2

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摘要 目的:探讨γ干扰素释放试验(IGRA)对高危患者肺结核(PTB)的诊断价值。方法:选择入住我院经全血IGRA T细胞斑点试验(T-SPOT.TB)检测结果明确的患者209例,其中,确诊为活动性结核(ATB组)155例、排除结核(非TB组)11例,未明确诊断(诊断不明确组)43例。按照相关标准,对全血IGRA T-SPOT.TB检测结果进行判读。结果:ATB组T-SPOT.TB检测的阳性率82.6%(128/155),非常显著高于非TB组的9.1%(1/11)(P<0.01)。T-SPOT.TB检测在高危患者群(ATB组)中诊断PTB的敏感度为82.6%(128/155),特异性为90.9%(10/11)。T-SPOT.TB检测结果明确209例中,阳性151例,阳性预测值84.8%(128/151);阴性39例,阴性预测值25.6%(10/39)。结论:IGRA T-SPOT.TB检测对高危患者PTB诊断具有较高的灵敏度和特异性,且阳性结果具有较高的支持诊断价值,阴性结果需谨慎排除诊断。
作者 潘燕玉 李津
出处 《人民军医》 2015年第7期794-795,803,共3页 People's Military Surgeon
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