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Haplotype Data of 23 Y-chromosome Markers in Minnan Han Chinese and Comparison with Those of 12 Y-chromosome Markers 被引量：2

Haplotype Data of 23 Y-chromosome Markers in Minnan Han Chinese and Comparison with Those of 12 Y-chromosome Markers
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摘要 We genotyped 23 Y-STR loci（DYS576, DYS389 I, DYS448, DYS389 II, DYS19, DYS391, DYS481, DYS549, DYS533, DYS438, DYS437, DYS570, DYS635, DYS390, DYS439, DYS392, DYS643, DYS393, DYS458, DYS385a/b, DYS456, and GATA-H4） in a sample of 109 unrelated male Chinese people residing in Minnan area and compared the results with those from our previous study on 12 Y-STR. The haplotype diversity and the discrimination capacity of the 23 Y-STR reached 0.9903 and 0.9725, respectively, and the genetic diversity for each locus ranged from 0.321（DYS391） to 0.955（DYS385）. Besides, we observed a strong correlation between the number of Y-STR markers and the substantial improvement of forensic parameters used to discriminate between individuals. The results indicated that these highly polymorphic Y-STR markers were useful for human identification in forensic cases and paternity tests within the Minnan Han Chinese population. We genotyped 23 Y-STR loci（DYS576, DYS389 I, DYS448, DYS389 II, DYS19, DYS391, DYS481, DYS549, DYS533, DYS438, DYS437, DYS570, DYS635, DYS390, DYS439, DYS392, DYS643, DYS393, DYS458, DYS385a/b, DYS456, and GATA-H4） in a sample of 109 unrelated male Chinese people residing in Minnan area and compared the results with those from our previous study on 12 Y-STR. The haplotype diversity and the discrimination capacity of the 23 Y-STR reached 0.9903 and 0.9725, respectively, and the genetic diversity for each locus ranged from 0.321（DYS391） to 0.955（DYS385）. Besides, we observed a strong correlation between the number of Y-STR markers and the substantial improvement of forensic parameters used to discriminate between individuals. The results indicated that these highly polymorphic Y-STR markers were useful for human identification in forensic cases and paternity tests within the Minnan Han Chinese population.
作者 尚杰 胡盛平
机构地区 Molecular Biology and Forensic Genetics Laboratory
出处 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2015年第3期456-463,共8页 华中科技大学学报（医学英德文版）
基金 supported by grants from the Li Ka-Shing Foundation(Hong Kong,China),Cambridge University,UK(No.432034) the Key Research Project of Shantou Science and Technology Bureau(No.2005116) the Shantou University Research and Development Fund(No.L00007)
关键词 Y-STR Minnan Han Chinese COMPARISON off-ladder Y-STR Minnan Han Chinese comparison off-ladder
分类号 R394 [医药卫生—医学遗传学]
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参考文献17

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Journal of Huazhong University of Science and Technology(Medical Sciences)
2015年 第3期

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