摘要
目的探索肾血管性高血压犬中颈动脉和冠状动脉粥样硬化特征的区别。方法10只雄性beagle犬随机均分为缩窄组及假手术组建立肾血管性高血压模型。术后1年经彩超证实颈动脉有粥样硬化形成后，分别对2组犬的颈动脉及冠状动脉行DSA及病理上H＆E、苏丹Ⅲ及MOVAT染色观察，比较其粥样硬化特征的区别。结果术后3月始，缩窄犬的平均收缩压（SBP）由术前的（138．80±9．20）mmHg升达峰值（171．20±3．56）mmHg，比较差异有统计学意义（P〈0．01）。1年后，5只DSA上缩窄犬有4只发现颈动脉有狭窄，有3只出现冠状动脉壁不光滑，但无明显狭窄（P〈0．05）；病理上缩窄犬颈动脉观察到由平滑肌细胞、蛋白聚糖和胶原纤维形成增殖性斑块，很少含脂质；冠状动脉内膜下观察到有脂质沉积，无明显细胞增殖现象。假手术犬两者均没有发现粥样硬化征象。结论肾血管性高血压犬中颈动脉易形成主要含平滑肌细胞、蛋白聚糖和胶原纤维的增殖性斑块，而冠状动脉粥样斑块形成不明显，只在内膜下有少量脂质沉积。
Objective To investigate the difference in atherosclerotic characteristics between carotid and coronary arteries in renovascular hypertensive canines. Methods Ten male beagles were used to establish renovascular hypertensive models and then were randomly divided into a constricted group and a sham-operated group, 5 for each group. One year after the operation, when atherosclerosis was verified by carotid color ultrasound, the difference in atherosclerotic characteristics was compared between carotid and coronary arteries using digital subtraction angiography, H＆E, Sudan ]I, and MOVAT stains. Results 3 months after the operation, the mean Systolic blood pressure （SBP） in constricted beagles increased from （138.80± 9.20） mmHg before the operation to a peak value （171.20 ± 3.56） mmHg, with a statistical difference （P 〈0.01）. One year after the operation, among the 5 constricted beagles, 4 had carotid stenosis and 3 have rough coronary artery walls but no stenosis （P 〈0.05）. Histological examination showed that carotid arteries had proliferative plaque formation, which was mainly comprised of smooth muscle cells, proteoglycans, and collagen fibers, but little lipid, and that coronary arteries had lipid deposit underneath intima but no obvious cell proliferation. No sign of atherosclerosis was observed on both carotid and coronary arteries in sham beagles. Conclusions The renovascular hypertensive beagles are liable to develop carotid proliferative plaques, which mainly consists of smooth muscle cells, proteoglycans, and collagen fibers; but coronary arteries doesn＇t develop obvious plaques, only have a little lipid deposit underneath intima.
出处
《国际医药卫生导报》
2015年第13期1784-1788,共5页
International Medicine and Health Guidance News
基金
广东省自然科学基金项目（S2013010015862）
广东省社会发展领域科技计划项目（2013B021800282）
广东省医学科研基金（A2010224）
