摘要
目的探讨p53和Ki67蛋白在胃癌中的表达及临床意义。方法选取2010年12月—2013年12月彭州市中医医院收治的胃癌患者68例作为胃癌组;另选取同期彭州市中医医院收治的胃炎患者66例作为胃炎组。观察两组患者p53和Ki67蛋白表达情况,按不同病理特征将胃癌患者分组并比较p53和Ki67蛋白的表达情况。结果胃癌组患者p53蛋白和Ki67蛋白阳性率高于胃炎组,差异有统计学意义(P<0.05);临床分期Ⅰ+Ⅱ期患者p53和Ki67蛋白阳性率低于临床分期Ⅲ+Ⅳ期患者,差异有统计学意义(P<0.05);浆膜下浸润患者p53和Ki67蛋白阳性率低于侵及浆膜患者(P<0.05);有淋巴结转移患者p53蛋白阳性率高于无淋巴结转移患者(P<0.05),有淋巴结转移患者Ki67蛋白阳性率与无淋巴结转移患者比较,差异无统计学意义(P>0.05);按分化程度情况分组,两组患者p53和Ki67蛋白阳性率比较,差异无统计学意义(P>0.05)。结论 p53和Ki67蛋白在胃癌中的表达率高,具有重要的临床意义。
Objective To explore the p53 and Ki67 protein expression and clinical significance in stomach neo-plasms. Methods A total of 68 stomach neoplasms patients were selected in the Traditional Chinese Medicine Hospital of Peng-zhou from December 2010 to December 2013 as stomach neoplasms group,66 gastritis patients were selected in the Traditional Chinese Medicine Hospital of Pengzhou from December 2010 to December 2013 as gastritis group. p53 and Ki67 protein expres-sion between the two groups were observed, according to different pathological feature in stomach neoplasms group, p53 and Ki67 protein expression were compared. Results p53 and Ki67 of stomach neoplasms group were higher than those of gastritis group（P〈0. 05）;p53 and Ki67 protein expression rates of clinical stageⅠ＋Ⅱ were lower than those of clinical stageⅢ＋Ⅳ（P〈0. 05）,p53 and Ki67 protein expression rates of subserosal invasion were lower than those of invading serosa（P〈0. 05 ）,p53 protein expression rates of patients with lymph node metastasis was higher than that of without lymph node metastasis （ P〈0. 05）,and Ki67 protein expression rate showed no significant differences（ P〉0. 05）;according to the degree of differ-entiation,p53 and Ki67 protein expression rate showed no significant differences（ P〉0. 05）. Conclusion p53 and Ki67 pro-tein expression in patients with stomach neoplasms are higher,has a great clinical significance.
出处
《临床合理用药杂志》
2015年第15期27-28,共2页
Chinese Journal of Clinical Rational Drug Use
