摘要
目的探讨甘露醇治疗急性脑梗死的临床效果。方法选取2011年8月—2013年5月徐州矿务集团第二医院收治的急性脑梗死患者80例,以抽签方式分为观察组与对照组,各40例。两组患者均予以常规治疗,对照组在常规治疗基础上加用川芎嗪、低分子右旋糖酐治疗,观察组在对照组基础上加用甘露醇治疗。观察两组患者临床疗效、美国国立卫生院神经功能缺损量表(NIHSS)评分及生活自理能力评定Barthel(BI)指数。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05),治疗后2、4、12周观察组患者NIHSS评分低于对照组(P<0.05);治疗前两组患者BI指数比较,差异无统计学意义(P>0.05),治疗后2、4、12周观察组患者BI指数高于对照组(P<0.05)。结论甘露醇治疗急性脑梗死的临床效果显著,可降低神经功能损害程度,改善患者预后。
Objective To explore the clinical effect of mannitol in the treatment of acute brain infarction. Methods A total of 80 patients with acute brain infarction were selected in the Xuzhou Mining Group Second Hospital from August 2011 to May 2013,according to lot drawing method,they were divided into observation group and control group,40 cases in each group. Both groups were given routine treatment,control group were given tetramethylpyrazine and low molecular dextran on the basis of routine treatment,observation group were given mannitol on the basis of control group. Clinical effect,NIHSS scores, BI index between the two groups were compared. Results The total effective rate of observation group was higher than that of control group（P 〈0. 05）;before treatment,NIHSS scores and BI index showed no significant differences between the two groups（P〉0. 05）,after treatment 2,4,12 weeks,NIHSS scores of observation group was higher than that of control group, BI index of observation group was lower than that of control group（ P〈0. 05）. Conclusion Mannitol has notable curative effect in the treatment of acute brain infarction,can reduce nerve function damage degree and improve the prognosis of patients.
出处
《临床合理用药杂志》
2015年第15期9-10,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
脑梗死
甘露醇
治疗结果
Brain infarction
Mannitol
Treatment outcome
