摘要
目的通过对代谢综合征(MS)常见中医证型的分析和血清脂肪因子水平的检测,研究MS患者中医证候规律及其与血清脂肪因子的相关性。方法对235例代谢综合征患者进行中医辨证分型,分为痰瘀互结组、痰浊阻遏组、气阴两虚组和阴虚热盛组,检测其血清脂肪因子,并对中医证候进行频数分析。结果痰瘀互结组和痰浊阻遏组血清瘦素(LEP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)、血清抵抗素(Resistin)、纤溶酶原激活物抑制物-1(PAI-1)水平较高,与气阴两虚组比较差异有统计学意义(P<0.05);痰瘀互结组和痰浊阻遏组血清脂联素(APN)水平较低,与气阴两虚组比较差异有统计学意义(P<0.05);气阴两虚组视黄醇结合蛋白-4(RBP4)较高,与其他3组比较差异有统计学意义(P<0.05)。代谢综合征中医症状、舌脉及病机出现的频次和频率具有一定规律,其病机出现的频次和频率由高到低依次为痰浊阻遏>痰瘀互结>气阴两虚>阴虚热盛。结论痰浊和血瘀可能是脂肪因子分泌及代谢异常并导致代谢综合征的关键病理环节。
Objective To investigate the relationship between traditional Chinese medicine(TCM)syndromes and serum adipokines in metabolic syndrome(MS).Methods Two hundreds and thirty five patients with MS were classified into four groups:Intermingled phlegm and blood stasis group,phlegm repressor groups,deficiency of both qi and yin group and yin deficiency and heat hyperactivity group.Serum adipokines were detected of MS,and then their TCM syndromes were counted by the frequency analysis.Results The relationship between serum fat factor and TCM syndromes showed that there was a higher level of the serum leptin(LEP),tumor nec-rosis factor α(TNF α),interleukin 6(IL 6),serum resistin and plasminogen activator inhibitor 1 (PAI 1)in both intermingled phlegm and blood stasis group and phlegm repressor group than that of deficiency of both qi and yin group,indicating a significantly statistical difference(P<0.05).The serum adiponectin(APN)level of intermingled phlegm and blood stasis group and phlegm re-pressor group were lower than that of deficiency of both qi and yin group,showing a significantly statistical differences(P<0.05). Compared with the other three groups,the retinol binding protein 4(RBP4)level was higher,there was a significantly statistical difference(P<0.05).TCM syndrome patterns of MS showed that the frequency of TCM symptoms tongue and pulse and pathogene-sis in MS patients had a certain regularity. The pathogenesis frequency was as fol ows phlegm repressor syndrome,intermingled phlegm and blood stasis syndrome,deficiency syndrome of both qi and yin,yin deficiency and heat hyperactivity syndrome in de-scending order.Conclusion Phlegm and blood stasis may be a key pathological aspects of adipokine secretion and metabolism and leading to MS.
出处
《中西医结合心脑血管病杂志》
2015年第6期720-724,共5页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
上海市卫生局中医药科研基金项目(No.2008L011A)
上海市卫生局中医药科研基金资助项目(No.2010L060A)
上海市中西医结合学会科研基金项目(No.zxyk-1205)
上海市中医药事业发展三年行动计划(重大研究)项目子课题(No.ZYSNXD-CC-ZDYJ042-02
ZYSNXD-CC-ZDYJ042-06)
关键词
代谢综合征
脂肪因子
中医证型
metabolic syndrome
adipokine
traditional Chinese medicine syndromes
