摘要
B细胞除了能通过产生抗体,提呈抗原来发挥免疫作用外,还有免疫抑制功能。机体内存在少量的调节性B细胞(Breg),能通过分泌抑制性细胞因子(如IL-10、肿瘤坏死因子等)或直接的细胞接触诱导免疫耐受、抑制过度炎症反应等,从而发挥免疫调节功能。B细胞在自身免疫性疾病、肿瘤免疫、抗感染免疫、移植耐受的维持等方面都发挥着重要作用。本文主要对Breg细胞的功能相关分子、作用机制以及与疾病的相关性等方面进行综述。
B cells not only can regulate the immune responses by producing antibody, presenting antigens to target immune cells, but also have the function of immune suppression. A small quantity of regulatory B （ Breg） cells in vivo is capable of performing regulatory functions by producing of inhibitory cytokines,such as interleukin -10, or by direct interaction with other immune cells. In vivo, Breg can maintain immune tolerance and inhibit excessive inflammatory responses efficiently. Clinical studies indicate that Breg are associated with some autoimmune diseases, cancers, infections, and transplantation tolerance. The review focuses on molecules associated with the differentiation and function of the Breg. And also, we discuss the mechanisms and the relations of Breg to clinical diseases.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2015年第3期326-330,354,共6页
Journal of International Pharmaceutical Research
