摘要
目的探究与分析结肠癌临床治疗及近期疗效观察。方法选取我院自2013年3月~2015年3月收治的59例结肠癌患者,采取随机数字表法分为奥沙利铂组30例与卡铂组29例,对比两组患者的近期疗效及不良反应。结果奥沙利铂组的总有效率为50.00%,卡铂组的总有效率为37.93%,奥沙利铂组的总有效率高于卡铂组（P〈0.05）。奥沙利铂组恶心呕吐、白细胞减少、血小板减少及口腔炎发病率均低于卡铂组,但神经毒性高于卡铂组（P〈0.05）。结论采用奥沙利铂联合亚叶酸钙及氟尿嘧啶治疗结肠癌的临床疗效显著,不良反应发生率较低,安全性较高。
Objective To explore and analyze the clinical treatment of colon cancer and term efficacy. Methods In our hospital from March 2013 to March 2015 were treated 59 cases of colon cancer patients, taken randomly divided into 30 cases of oxaliplatin, carboplatin group and 29 patients, compared two groups of patients with recent efficacy and adverse reactions. Results The total effective rate of oxaliplatin group 50.00%, the total effective rate of carboplatin group 37.93%, of the total oxaliplatin group was significantly higher than carboplatin group（P〈0.05）. Oxaliplatin group nausea and vomiting, leukopenia, thrombocytopenia, and stomatitis incidence rates were significantly lower than carboplatin group, but significantly higher than the neurotoxicity of carboplatin（P〈0.05）. Conclusion The clinical efficacy of oxaliplatin combined with leucovorin and fluorouracil treatment of colon cancer was significantly lower incidence of adverse reactions, high security.
出处
《中国继续医学教育》
2015年第15期80-81,共2页
China Continuing Medical Education
关键词
结肠癌
奥沙利铂
卡铂
亚叶酸钙
氟尿嘧啶
Colon cancer
Oxaliplatin
Carboplatin
Calcium folinate
Fluorouracil
