摘要
目的：观察蠲哮片辅助治疗支气管哮喘热哮发作期的临床疗效及对白细胞介数-6（IL-6）,IL-8,IL-10水平的影响。方法：将125例患者采用随机按数字表法分为观察组64例和对照组61例。对照组采用硫酸沙丁胺醇气雾剂,每次1~2喷,必要时可每隔4~8 h喷入1次;重者加用布地奈德鼻喷雾剂,每个鼻孔各2喷,早、晚各1次。观察组在对照组治疗的基础上加服蠲哮片,8片/次,3次/d。两组疗程均为2周。进行治疗前后喘息、胸闷、咯痰、咳嗽、哮鸣音等主要症状和哮喘控制问卷（ACQ）评分;评价治疗前后1 s用力呼气容积（FEV1）,第1秒钟用力呼气容积与用力肺活量比值（FEV1/FVC）,呼气峰值流速（PEF）,呼气峰值流速占预计值百分比（PEF%pred）等肺功能指标;检测治疗前后IL-6,IL-8,IL-10水平,并进行外周血嗜酸性粒细胞（EOS）计数。结果：观察组临床疗效总有效率为95.31%,对照组为81.97%,观察组优于对照组（P〈0.05）;治疗后观察组喘息、胸闷、咯痰、咳嗽、哮鸣音评分低于对照组（P〈0.01）;治疗后观察组FEV1%pred,FEV1/FVC,PEF,PEF%pred均高于对照组（P〈0.01）;治疗后观察组IL-6和IL-8水平低于对照组,IL-10水平高于对照组（P〈0.01）;治疗后观察组EOS计数少于对照组,ACQ评分低于对照组（P〈0.01）。结论：蠲哮片辅助治疗支气管哮喘发作期（热哮）能减轻临床症状,改善肺功能,控制哮喘发作,其作用机制可能与调节炎症因子,减轻气道炎症反应有关。
Objective： To observe the curative efficacy of Juanxiao tablets for assistance in treating episodes of bronchial asthma of hot asthma syndrome,and to investigate its influence on levels of interleukin IL-6,IL-8 and IL-10. Method： One hundred and twenty-five patients were randomly divided into the control group（ 61cases） and the observation group（ 64 cases） by a random number table. Patients in the control group received 1-2spray salbutamol aerosols,and once every 4-8 h when necessary. For heavy patients,Budesonide nasal spray was added,2 sprays to nostrils at morning and evening. Based on the treatment of the control group,patients in the observation group added 8 Juanxiao tablets thrice daily. All patients in both two groups received 2 weeks of treatment. The main symptoms including breathing,chest tightness,cough up phlegm,coughing,wheezing sound and asthma control questionnaire（ ACQ） were graded before and after treatment. Lung function indexes such as forced expiratory volume in one second（ FEV1）,forced expiratory volume in first second（ FEV1/ FVC） and forced vital capacity ratio,peak expiratory flow（ PEF）,peak expiratory flow rate prediction percentage（ PEF%pred） were evaluated. Levels of IL-6,IL-8,IL-10 and peripheral blood eosinophil（ EOS） were tested. Result： The clinical efficacy of total effective rate in the observation group was 95. 31%,which was superior to that of 81. 97% in the control group（ P〈0. 05）. After therapy,scores of breathing,chest tightness,cough up phlegm,coughing,wheezing sound in the observation group were lower than those in the control group（ P〈0. 01）. The FEV1%pred,FEV1/ FVC,PEF,PEF%predin the observation group were higher than those in the control group（ P〈0. 01）.After treatment,levels of IL-6 and IL-8 in the observation group were lower,while IL-10 level was higher than those in the control group（ P〈0. 01）. The EOS and ACQ scores in the observation group were inferior to those in the control group（ P〈0. 01）. Conclusion： Juanxiao tablets could reduce clinical symptoms,improve lung function and control asthma in treating episode of bronchial asthma at（ hot asthma syndrome）. Its mechanism may be related to modulating inflammatory factor and reducing airway inflammation.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第13期186-189,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
支气管哮喘
热哮
蠲哮片
炎症反应
嗜酸性粒细胞
bronchial asthma
hot asthma
Juanxiao tablets
inflammatory response
eosinophils
