摘要
目的了解不同妊娠时期胎儿生长受限(FGR)时母体血中神经轴突导向因子-1(Netrin-1)水平,以进一步探讨FGR的发病机制。方法选取2013年6月—2014年6月不同妊娠时期73例孕妇为研究对象,其中经超声诊断FGR患者28例(孕中期18例,孕晚期10例)纳入研究组,相应孕周正常孕妇45例(孕早期10例,孕中期23例,孕晚期12例)纳入对照组。测定母体外周静脉血血清Netrin-1水平及分析相应胎儿核型。结果 73例患者中除1例胎儿核型为18-三体外,其他患者核型正常。正常孕早、中及晚期母体血清Netrin-1水平为(220.25±10.72)pg/ml、(23.10±1.08)pg/ml及(1000.62±98.14)pg/ml,FGR患者孕中、晚期母体血清Netrin-1水平为(22.24±0.96)pg/ml及(35.13±0.96)pg/ml。与妊娠早、中期相比,正常母体外周血中Netrin-1水平于妊娠晚期达到最高值(均P<0.05)。与正常妊娠相比,FGR患者孕中期母体外周血中Netrin-1水平无明显变化(P>0.05),但FGR孕晚期患者外周血中Netrin-1水平下降明显(P<0.05)。结论 FGR发生可能与母体血Netrin-1水平,尤其是孕晚期Netrin-1水平有关。同时胎儿染色体异常在FGR发生过程中亦起到一定作用。
Objective To explore the serum level of neuron towards axon guidance factor-1（ Netrin-1） in pregnancies complicated by fetal growth restriction（ FGR）,and investigate the mechanism of Netrin-1 in fetal growth restriction. Methods A total of 73 consecutive cases of pregnant women from June 2013 to June 2014 in our hospital were analyzed. The28 pregnant women with fetal growth restriction diagnosed by ultrasonography were served as test group,among them 18 cases were in the midtrimester,10 cases in the third trimester. The corresponding 45 pregnant women were treated as control group,among them 10 cases were in the first-trimester,23 cases in the midtrimester and 12 cases in the third trimester. The serum levels of Netrin-1 were detected in all pregnant women and the fetal karyotype were analyzed in the corresponding fetus. Results There were 72 cases with normal karyotype,only one was 18 trisomy syndrome. The maternal serum level of Netrin-1 in normal early pregnancy,medium term pregnancy and term pregnancy were（220. 25 ± 10. 72） pg /ml,（23. 10 ± 1. 08） pg / ml and（1000. 62 ± 98. 14） pg / ml,respectively. The maternal serum level of Netrin-1 in medium term pregnancy and term pregnancy complicated by fetal growth restriction were（ 22. 24 ± 0. 96） pg / ml and（ 35. 13 ±0. 96） pg / ml. Compared with the levels in the early pregnancy and medium term pregnancy,the maternal serum level of Netrin-1 in term pregnancy was higher（ P 〈0. 05）,but there were no significant differences between the two groups with mediumterm pregnancy（ P 〉0. 05）,and the maternal serum level of Netrin-1 in term pregnancy were decreased significantly than the normal term pregnancy（ P 〈0. 05）. Conclusion The maternal serum level of Netrin-1 may be involved in the development of fetal growth restriction,especially in term pregnancy,and fetal chromosomal abnormalities maybe also take part in it.
出处
《中华全科医学》
2015年第8期1288-1289,1292,共3页
Chinese Journal of General Practice
基金
浙江省卫生厅基金(2013KYB261)
浙江省嘉兴市科技局基金(2012AY1073-1
2012AY1073-5)
