摘要
维甲酸相关孤儿受体属于类固醇激素受体超家族;在机体免疫系统的分化成熟中至关重要,其在次级淋巴组织发育、T淋巴细胞分化成熟及T细胞的谱系分化过程中均起重要作用。近年来,人们通过深入研究进一步阐明了该受体为配体依赖的转录因子;并揭示了其在一些疾病过程中的作用,包括自身免疫病及肿瘤。该文对其相关研究进行综述。
Retinoid-related orphan receptors are transcription factors belonging to the steroid hormone receptor superfamily; they play critical roles in immune system,as revealed in several studies that they are essential for the development of lymphoid tissues,differentiation and maturation of T lymphocytes and T cell lineage specification.Recent reports confirmed the receptors are ligand dependent transcription factors and revealed their roles in some diseases,including several autoimmune diseases and tumors.Here is to make a review of the preceding aspects of the receptors.
出处
《医学综述》
2015年第11期1937-1939,共3页
Medical Recapitulate
基金
天津市应用基础及前沿技术研究计划(11JCYBJC27700)
关键词
维甲酸相关孤儿受体
类固醇激素受体
免疫
Retinoid--related orphan receptors
Steroid hormone receptor
Immunity
