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铂类药物在儿童实体瘤化疗中的应用 被引量：2

Application of platinum drugs in chemotherapy for childhood solid tumors
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摘要 儿童实体瘤包括神经母细胞瘤、肝母细胞瘤、肾母细胞瘤、生殖细胞瘤、骨肉瘤、视网膜母细胞瘤及脑瘤等。在实体瘤治疗中铂类药物应用广泛,其中最主要的三种铂类药物为顺铂、卡铂和奥沙利铂。本文回顾铂类药物的作用特点及其毒性,简要综述近年相关临床应用研究。 Platinum based chemotherapies are widely used in the treatment of pediatric solid tumors, including neuroblastoma, hepatoblastoma, Wilms＇ tumor, germ cell tumors, osteosarcoma, retinoblastoma and brain tumors. So far, three kinds of platinum drugs, cisplatin, carboplatin and oxaliplatin are popularly used in clinics. This review focuses on the characteristics, toxicities and clinical application of platinum drugs.
作者 曲奎尧 唐锁勤
机构地区 解放军总医院儿科 解放军第
出处 《世界临床药物》 CAS 2015年第5期305-309,共5页 World Clinical Drug
基金 国家863计划项目(2012AA020804)
关键词 铂类 儿童 实体瘤 platinum children solid tumor
分类号 R979.1 [医药卫生—药品] R720.5 [医药卫生—儿科]
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参考文献30

  • 1Macy ME, Duncan T, Whitlock J, et al. A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leueovorin in pediatric patients with advanced solid tumors [J]. Pediatr Blood Cancer. 2013, 60 (2) : 230-236.
  • 2Go RS, Adjei AA. Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin[J]. J Clin Oncol, 1999, 17(1):409-422.
  • 3O'Dwyer P J, Stevenson JP, Johnson SW. Clinical pharmacokinetics and administration of established platinum drugs[J]. Drugs, 2000, 59 (Suppl 4): 19-27.
  • 4Veal GJ, Errington J, Tilby MJ, et al. Adaptive dosing and platinum-DNA adduct formation in children receiving high- dose carboplatin for the treatment of solid tumours [J]. Br J Cancer, 2007, 96 (5): 725-731.
  • 5Ruggiero A, Trombatore G, Triarico S, et a/.Platinum compounds in children with cancer: toxicity and clinical management[J]. Anticancer Drugs, 2013, 24 (10) : 1007-1019.
  • 6Lokich J, Anderson N. Carboplatin versus cisplatin in solid tumors: ananalysis of the literature [J]. Ann Oncol, 1998, 9(1):13-21.
  • 7Brock PR, Knight KR, Freyer DR, et al. Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale [J]. J Clin Oncol, 2012, 30 (19) : 2408-2417.
  • 8Choeyprasert W, Sawangpanich R, Lertsukprasert K, et al. Cisplatin-induced ototoxicity in pediatric solid tumors: the role of glutathione S-transferases and megalin genetic polymorphisms EJl. J Pediatr Hematol Oneol, 2013, 35 (4): e138-e143.
  • 9Grewal S, Merchant T, Reymond R, et al. Auditory late effects of childhood cancer therapy: a report from the children's oncology group [J]. Pediatrics, 2010, 125 (4) : 938-950.
  • 10Cushing B, Giller R, Cullen JW, et al. Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study-Pediatric Oncology Group 9049and Children's Cancer 8882 [J]. J Clin Onco, 2004, 22 (13): 2691-2700.

二级参考文献11

  • 1Mattano LA Jr,Moss TJ,Emerson SG. Sensitive detection of rare circulating neuroblastoma ceils by the reverse transcriptasepolymerase chain reaction[J].{H}CANCER RESEARCH,1992,(17):4701-4705.
  • 2Stram DO,Matthay KK,O'Leary M. Consolidation chemoradiotherapy and autologous bone marrow transplantation versus continued chemotherapy for metastatic neuroblastoma:a report of two concurrent Children's Cancer Group studies[J].{H}Journal of Clinical Oncology,1996,(9):2417-2426.
  • 3Vogelzang N J,Benowitz SI,Adams S. Clinical cancer advances 2011:Annual Report on Progress Against Cancer from the American Society of Clinical Oncology[J].{H}Journal of Clinical Oncology,2012,(1):88-109.
  • 4Castel V,Tovar JA,Costa E. The role of surgery in stage Ⅳ neuroblastoma[J].{H}Journal of Pediatric Surgery,2002,(11):1574-1578.
  • 5Wilson JS,Gains JE,Moroz V. A systematic review of 1311-meta iodobenzylguanidine molecular radiotherapy for neuroblastoma[J].{H}EUROPEAN JOURNAL OF CANCER,2013.
  • 6Kreissman SG,Seeger RC,Matthay KK. Purged versus non-purged peripheral blood stem-cell transplantation for highrisk neuroblastoma (COG A3973):a randomised phase 3 trial[J].{H}LANCET ONCOLOGY,2013,(10):999-1008.
  • 7Yu AL,Uttenreuther-Fischer MM,Huang CS. Phase Ⅰ trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma[J].{H}Journal of Clinical Oncology,1998,(6):2169-2180.
  • 8Handgretinger R,Anderson K,Lang P. A phase Ⅰ study of human/mouse chimeric antiganglioside GD2 antibody ch14.18 in patients withneuroblastoma[J].{H}EUROPEAN JOURNAL OF CANCER,1995,(2):261-267.
  • 9Yu AL,Gilman AL,Ozkaynak MF. Ami-GD2 antibody with GM-CSF,interleukin-2,and isotretinoin for neuroblastoma[J].{H}New England Journal of Medicine,2010,(14):1324-1334.
  • 10Morgenstern DA,Baruchel S,Irwin MS. Current and future strategies for relapsed neuroblastoma:challenges on the road to precision therapy[J].{H}Journal of Pediatric Hematology Oncology,2013,(5):337-347.

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世界临床药物
2015年 第5期

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