摘要
目的探讨银杏达莫注射液联合亚低温治疗对重型颅脑损伤患者手术效果的影响。方法选择2013年1月—2014年7月南京中医药大学江阴附属医院收治的重型颅脑损伤患者60例,随机分为观察组和对照组,各30例。两组患者入院后均给予综合治疗,对照组患者采用改良去大骨瓣减压术治疗,观察组在对照组基础上给予银杏达莫注射液联合亚低温治疗。比较治疗前、治疗4周两组患者血清清蛋白(ALB)、丙二醛(MDA)和超氧化物歧化酶(SOD)水平变化;比较治疗前、治疗2周、治疗4周两组患者格拉斯哥昏迷量表(GCS)评分;治疗6个月评定两组患者格拉斯哥预后量表(GOS)分级。结果治疗前两组患者ALB、MDA、SOD水平比较,差异无统计学意义(P>0.05);治疗4周观察组患者ALB、SOD水平高于对照组,MDA水平低于对照组(P<0.05)。治疗前两组患者GCS评分比较,差异无统计学意义(P>0.05);治疗2周、4周观察组患者GCS评分高于对照组(P<0.05)。观察组患者GOS分级优于对照组(P<0.05)。结论银杏达莫注射液联合亚低温治疗能明显提高重型颅脑损伤患者手术效果,减轻颅脑损伤程度,从而改善患者预后。
Objective To investigate impact of ginkgo - dipyridolum injection combined with sub - hypothermia therapy on surgical effect of severe craniocerebral trauma. Methods From January 2013 to July 2014, a total of 60 patients with severe eraniocerebral trauma were selected in Jiangyin Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, and they were randomly divided into control group and observation group, 30 eases in each. Patients of both groups were given comprehensive treatments after admission and modified large bone flap craniectomy, while patients of observation group were given ginkgo - dipyridolum injection combined with sub - hypothermia therapy. Albumin （ ALB ）, methane diearboxylic aldehyde （MDA） and superoxide dismutase （SOD） were compared between the two groups before treatment and after 4 weeks of treatment; Glasgow Coma Scale （GCS） was evaluated before treatment, after 2 weeks and 4 weeks of treatment; Glasgow Outcome Scale （GOS） grading was compared between the two groups after 6 months of treatment. Results No statistically significant differences of ALB, MDA or SOD was found between the two groups before treatment （ P 〉 0. 05 ） ; ALB and SOD of observation group were statistically significantly higher than those of control group after 4 weeks of treatment, while MDA of observation group was statistically significantly lower than that of control group after 4 weeks of treatment （ P 〈 0. 05 ）. No statistically significant differences of GCS score was found between the two groups before treatment （ P 〉 0. 05 ） , but GCS score of observation group was higher than that of control group after 2 weeks and 4 weeks of treatment, respectively （ P 〈 0. 05 ）. GOS grading of observation group was statistically significantly better than that of control group after 6 months of treatment （ P 〈 0. 05 ）. Conclusion Ginkgo - dipyridolum injection combined with sub - hypothermia therapy can improve the surgical effect of severe cranioeerebral trauma, reduce the severity of craniocerebral trauma and improve the prognosis.
出处
《实用心脑肺血管病杂志》
2015年第4期69-72,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
颅脑损伤
减压颅骨切除术
银杏达莫注射液
亚低温疗法
治疗结果
Craniocerebral trauma
Decompressive craniectomy
Ginkgo - dipyridolum injection
Sub - hypothermiatherapy
Treatment outcome
