摘要
目的:探讨关节腔内注射氨甲环酸(TXA)对同期双侧人工全髋关节置换(THA)术后失血量的影响。方法:同期双侧THA患者42例,关节腔内使用TXA 21例为观察组,使用生理盐水21例为对照组,比较两组患者术后24 h引流量、输血量、术后血红蛋白水平、总失血量、隐性失血量,纤维蛋白原(Fbg)、凝血酶原时间(PT)和活化部分凝血酶原时间(APTT),并观察患者3月内是否发生深静脉血栓(DVT)及肺栓塞(PE)。结果:观察组术后总的失血量、术后24 h引流量、隐性失血量、输血量低于对照组,血红蛋白水平高于对照组,差异均有统计学意义(P<0.05);两组患者的凝血3项指标比较差异无统计学意义(P>0.05)。未发现深静脉血栓及肺栓塞病例。结论:THA关节腔内使用TXA能明显降低患者术后失血量并减少输血率,不增加术后PE及VTE的发生率。
Objective： To investigate the efficacy of applying tranexamic acid in articular cavity on blood loss after simultaneous bilateral total hip arthroplasty（ THA）. Methods： A total of 42 patients who underwent the simultaneous bilateral THA surgery were observed. 21 as observer group had received tranexamic acid in their articular cavity,while the rest 21 as control group had not received any tranexamic acid. Comparing the postoperative transfusion rate,postoperative hemoglobin values 24 hours after they had the THA surgery,changes in postoperative fibrinogen（ Fbg）,prothrombin time（ PT） and activated partial prothrombin time（ APTT） before and after the THA surgery. Observing whether patients suffered from symptomatic deep vein thrombosis（ DVT） and pulmonary embolism（ PE） within 3 months. Results： Total blood loss,postoperative drainage volume within 24 hours,hidden blood loss and blood transfusion in observation group were lower than those of control group,hemoglobin level was higher than control group,differences were statistically significant（ P〈0. 05）. However,3 indexes of thrombin were not statistically insignificant（ P〉0. 05）. Both two groups of patients did not suffer DVT or PE. Conclusions： Application of tranexamic acid in the articular cavity of patients after they receive THA
出处
《贵阳医学院学报》
CAS
2015年第5期500-503,共4页
Journal of Guiyang Medical College
基金
贵州省关节与脊柱疾病诊治研究创新人才团队[(2011)4102号]
关键词
氨甲环酸
全髋关节置换术
失血
手术
输血
深静脉血栓
肺栓塞
tranexamic acid
total hip arthroplasty
blood loss, surgical
blood transfusion
deep vein thrombosis
pulmonary embolism
