摘要
目的探讨直肠癌患者手术治疗前后血清同型半胱氨酸(Hcy)、血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)水平变化,为加强临床观察疗效及评估预后提供依据。方法选择2012年1月至2013年12月来我院进行手术治疗的60例直肠癌患者为研究对象,另选取同期体检健康者30例,循环酶法测定血清Hcy水平,酶联免疫吸附法测定血清VEGF、TGF-β1水平,观察患者治疗前后Hcy、VEGF、TGF-β1水平变化,分析其与预后关系。结果直肠癌患者血清Hcy、VEGF、TGF-β1水平显著高于正常对照组(t值分别为10.847、37.196、31.458,均P<0.05);手术治疗后患者Hcy、VEGF、TGF-β1水平与治疗前比较明显降低(t值分别为7.284、30.045、28.672,均P<0.05),术后12个月,未复发患者Hcy、VEGF、TGF-β1水平逐渐下降,复发组患者血清Hcy、VEGF、TGF-β1水平升高与术前水平相近,复发组显著高于未复发组(t值分别为9.489、35.917、29.846,均P<0.05);Hcy、VEGF、TGF-β1水平与TNM分期、肿瘤大小有关(F值分别为3.758、15.376、4.948,t值分别为3.625、21.473、8.975,均P<0.05)。结论直肠癌患者手术治疗前后血清Hcy、VEGF、TGF-β1水平有助于临床疗效观察及评估预后。
Objective To investigate the clinical significance of serum homocysteine Hey, vascular endothelial growth factor （VEGF）, transforming growth factor （TGF-β1） levels in the treatment of colorectal cancer patients before and after surgery, in order to provide the basis for strengthening the assessment of the clinical efficacy and prognosis. Methods 60 cases of colorectal cancer patients from January 2012 to December 2013 in our hospital for surgical treatment were selected, 30 cases of healthy subjects were selected at the same period, serum Hey levels was tested by enzymatic eyele, serum VEGF, TGF-β1 levels were measured by enzyme-linked immunosorbent assay, before and aider treatment Hey, VEGF, TGF-β1 levels were observed, its relationship with prognosis were analyzed. Results The serum Hey, VEGF, TGF-β1 levels of colorectal cancer were significantly higher than the control group （t=-10.847, 37.196, 31.458, P〈0.05）; after surgery Hey, former VEGF, TGF-β1 levels in patients were significantly lower than those before treatment （t=7.284, 30.045, 28.672, P〈0.05）, surgery after six months, patients without recurrence Hey, VEGF, TGF-131 levels gradually decreased, patients with recurrence Hey, VEGF, TGF-β1 levels increased, with similar level of preoperative. Patients with recurrence Hey, VEGF, TGF-β1 levels were significantly higher than non-recurrence group （t=9.489, 35.917, 29.846, P〈0.05）; Hey, VEGF, TGF-β1 levels were positively correlated with TNM stage, tumor size （F=3.758, 15.376, 4.948, t=-3.625, 21.473, 8.975, P〈0.05）. Conclusion It shows that in eolorectal cancer patients before and after surgery serum Hcy, VEGF, TGF-β1 levels contribute to the clinical efficacy and assess prognosis.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第10期58-61,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
武汉市科技局应用基础研究项目(2013062301010823)
武汉市卫计委医疗科研项目(WX14A11)
关键词
直肠肿瘤
血管内皮生长因子类
转化生长因子Β1
高半胱氨酸
Rectal neoplasms
Vascular endothelial growth factors
Transforming growthfactor betal
Homocysteine
