摘要
目的探讨引发失代偿期乙型肝炎肝硬化患者医院感染的相关因素,以期为预防、控制感染的发生发展和提高患者的预后提供参考。方法选择2010年1月-2014年6月医院收治的206例失代偿期慢性乙型肝炎肝硬化患者为研究对象,回顾性分析引发失代偿期慢性乙型肝炎肝硬化患者医院感染的危险因素。结果 206例失代偿期慢性乙型肝炎肝硬化患者发生医院感染36例,感染率为17.5%;易感染部位依次为呼吸道、腹膜、消化道、泌尿系统及其他部位,分别占41.7%、27.8%、16.7%、8.3%及5.5%;单因素分析结果显示,年龄≥60岁、住院时间≥30d、实施侵入性治疗、血清白蛋白<30g/L、血白细胞<4×109/L、有并发症、应用抗病毒药物、预防性应用抗菌药物、肝功能Child分级为医院感染的相关因素(P<0.05);多因素回归分析显示,年龄≥60岁、住院时间≥30d、实施侵入性治疗、有并发症、预防性应用抗菌药物、肝功能Child分级是引发失代偿期乙型肝炎肝硬化患者医院感染的独立危险因素(P<0.05)。结论引起失代偿期慢性乙型肝炎肝硬化患者医院感染因素很多,在治疗过程中应有针对性采取有效措施进行预防,降低患者医院感染发生率。
OBJECTIVE To explore the related factors for nosocomial infections in the patients with decompensated chronic hepatitis B cirrhosis so as to provide guidance for control and prevention of the infections and improve the prognosis .METHODS A total of 206 patients with decompensated chronic hepatitis B liver cirrhosis who were trea‐ted in the hospital from Jan 2010 to Jun 2014 were recruited as the study objects ,then the risk factors for the nos‐ocomial infections in the patients with decompensated chronic hepatitis B liver cirrhosis were retrospectively ana‐lyzed .RESULTS The nosocomial infections occurred in 36 of 206 patients with decompensated chronic hepatitis B liver cirrhosis ,with the infection rate of 17 .5% .Of the patients with nosocomial infections ,41 .7% had the re‐spiratory tract infections ,27 .8% had the peritoneal infections ,16 .7% had the gastrointestinal tract infections , 8 .3% had the urinary tract infections ,and 5 .5% had other sites of infections .The results of the univariate analy‐sis showed that the nosocomial infections were associated with the no less than 60 years of age ,length of hospital stay no less than 30 days ,invasive operation ,level of serum albumin less than 30g/L ,white blood cell counts less than 4 × 109/L ,complications ,use of antiviral drugs ,antibiotics prophylaxis ,and Child classification of liver function （P〈0 .05） .The multivariate regression analysis indicated that the no less than 60 years of age ,length of hospital stay no less than 30 days ,invasive operation ,complications ,antibiotics prophylaxis ,and Child classifica‐tion of liver function were the independent risk factors for the nosocomial infections in the patients with decompen‐sated chronic hepatitis B liver cirrhosis （P〈0 .05） .CONCLUSION There are a variety of risk factors for the noso‐comial infections in the patients with decompensated chronic hepatitis B liver cirrhosis ,and it is necessary to take targeted prevention measures during the treatment so as to reduce the incidence of the nosocomial infections .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第12期2787-2789,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(30225039)
关键词
失代偿期
慢性乙型肝炎
肝硬化
医院感染
影响因素
Decompensation period
Chronic hepatitis B
Liver cirrhosis
Nosocomial infection
Influencing factor
