摘要
目的探讨终末期肾病(ESRD)患者腹膜透析(PD)和血液透析(HD)对自然杀伤(NK)细胞和T细胞亚群的影响。方法 2013年1月至12月诊治的25例ESRD患者中PD组13例,HD组12例。分别比较两组患者透析前、透析后6个月及12个月时,患者NK细胞和T细胞亚群的变化。结果 (1)PD治疗组:PD后6、12个月CD3+、CD4+、CD4/CD8较透析前均升高(P均<0.05);PD后12个月CD3+、CD4+均高于PD后6个月(P均<0.05),但CD4/CD8无明显变化(P>0.05)。PD后6个月与透析前、PD后12个月相比,CD8+无统计学差异(P>0.05)。NK细胞(CD16+/CD56+)百分比在PD后6、12个月较透析前均降低(P均<0.05),且PD后12个月低于PD后6个月(P<0.05)。(2)HD治疗组:HD后6、12个月CD3+、CD4+、CD4/CD8与透析前相比均升高(P均<0.05),CD8+无变化(P>0.05);HD后12个月与HD后6个月相比CD3+下降(P<0.05),CD4+、CD4/CD8无变化(P均>0.05);NK细胞百分比在HD后6个月与透析前相比无差异(P>0.05);HD后12个月较透析前及HD后6个月均降低(P均<0.05)。结论 PD治疗对ESRD患者T细胞免疫功能的抑制低于HD治疗,两种透析方法对NK细胞活性的降低无差别。
Objective To investigate the influences of peritoneal dialysis （PD） versus hemodialysis （HD） on natural kil- ler （NK） cells and T cell subsets in patients with end-stage renal disease （ESRD）. Methods From January 2013 to De- cember 2013 ,twenty-five patients with ESRD were divided into PD group （n = 13 ） and HD group （n = 12） according to dialysis methods. The changes of NK cells and T cell subsets before dialysis and 6,12 months after dialysis were compared. Results In PD group, CD3 ＋ , CD4 ＋ , CD4/CD8 at 6 and 12 months after PD raised significantly compared with pre-dialy- sis （ all P 〈 0.05 ） ; CD3 ＋ , CD4 ＋ at 12 months after PD were higher than those at 6 months after PD （ all P 〈 0.05 ）, but CD4/CD8 remained unchanged （P 〉0. 05）;the CD8 ~ among pre-dialysis, 6 and 12 months after dialysis were similar （ P 〉 0.05 ）. The percentages of NK cells （ CD16 ＋/CD56 ＋ ） at 6 and 12 months after PD decreased compared with pre-di- alysis （ all P 〈 0.05 ）, and it of 12 months after dialysis was lower than that of 6 months （ P 〈 0.05 ）. In HD group, CD3 ＋ , CD4＋ , CIM/CD8 at 6 and 12 months after HD raised significantly compared with pre-dialysis （ all P 〈 0.05 ） , while CD8 ＋ remained unchanged （ P 〉 0. 05 ）. Compared with 6 months after HD, CD3 ~ of 12 months after HD decreased （ P 〈 O. 05 ） , while CD4＋ , CIM/CD8 remained unehanged（ all P 〉 0.05 ）. The percentage of NK cells at 6 months after dialysis was sim- ilar to pre-HD （ P 〉0. 05 ） ,but it of 12 months after HD was lower than those of pre-dialysis and 6 months after HD （ all P 〈0. 05 ）. Conclusion The suppressive effect of PD on T cell immunologic functions is lower than that of HD, while PD and HD induced lowering of NK cells activity is similar in ESRD patients.
出处
《中国临床研究》
CAS
2015年第5期548-550,共3页
Chinese Journal of Clinical Research
基金
国家自然科学基金资助项目(81070366)
关键词
终末期肾病
腹膜透析
血液透析
自然杀伤细胞
T细胞亚群
End-stage renal disease
Peritoneal dialysis
Hemodialysis
Natural killer cell
T cells subsets
