摘要
目的分析川崎病住院患儿的临床表现及辅助检查相关指标与心血管系统的并发症之间的关系,为川崎病的治疗提供指导。方法 2008年1月至2013年1月温岭市妇女儿童医院儿科收住的川崎病患儿56例为研究对象,入院后收集患儿的临床资料,查体并行相关辅助检查,对上述指标进行统计学分析。结果①56例川崎病患儿合并心血管系统损害的有34例,占总人数的60.71%。其中心电图异常12例(21.43%),心脏彩超异常31例(55.36%),两者均异常者9例;②多因素Logistic回归分析提示:C-反应蛋白(CRP)OR=1.786,就诊前发热持续时间(OR=1.345),血小板计数(PLT)OR=2.565,与川崎病患儿心血管系统损害均有显著意义(均P<0.05)。结论川崎病患儿早期发生心血管系统损害的比率高,CRP、就诊前发热持续时间和PLT是心血管系统损害的高危因素,在发病早期应以上因素高度重视。
Objective To investigate the clinical manifestations of hospitalized children with Kawasaki disease and the correlation between indexes of auxiliary examination and the complications of cardiovascular system, so as to provide some guidance for treatment of the disease.Methods The study included 56 children with Kawasaki disease hospitalized in pediatric department of Wenling Women and Children’ s Hospital during the period of January 2008 to January 2013.The clinical data of the children were collected.They took physical examination and some auxiliary examinations.All of the indexes were analyzed statistically.Results Totally 34 of 56 cases of Kawasaki disease were complicated with cardiovascular damages, accounting for 60.71%.There were 12 cases （21.43%） with abnormal ECG and 31 cases with abnormal cardiac ultrasonic results （55.36%）.Nine cases suffered both.Multivariate Logistic regression analysis showed that CRP （OR=1.786）, duration of fever before treatment （OR=1.345） and PLT （OR=2.565） were significantly correlated with cardiovascular damages in children with Kawasaki disease （all P〈0.05）.Conclusion The incidence of cardiovascular damages on children with Kawasaki disease at early stage is high.CRP, heating duration before treatment and PLT are high-risk factors of cardiovascular damages, therefore, much attention should be paid to the above factors at early stage.
出处
《中国妇幼健康研究》
2015年第2期280-281,309,共3页
Chinese Journal of Woman and Child Health Research
关键词
儿童
川崎病
临床表现
心血管病变
并发症
children
Kawasaki disease
clinical manifestations
cardiovascular disease
complication
