摘要
肌少症是以骨骼肌质量、力量以及功能降低为主要特征的退行性综合征。年龄与肌少症密切相关,然而,慢性肾脏病尤其终末期肾病可加速肌肉消耗,增加肌少症发生率。导致尿毒症肌少症因素较多,如激素、免疫和肌细胞的改变,代谢性酸中毒,蛋白质摄入减少及运动减少等。尿毒症合并肌少症发生率高,且死亡率高,因而,需要早期预防、早期诊断和治疗。
Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Ageing is associated with sarcopenia, and end-stage renal disease accelerates the normal physiological muscle wasting resulting in an increasing prevalence of sarcopenia, which is named uraemic sarcopenia. There are several mechanisms that may be involved in the onset and progression of uraemic sarcopenia, such as hormones, changes in immune and muscle cells, metabolic acidosis, reducing protein intake and so on. Uraemic sarcopenia presents a high probability for morbidity and mortality, and consequently a high priority for muscle wasting prevention and treatment in these patients.
出处
《肾脏病与透析肾移植杂志》
CSCD
北大核心
2015年第2期181-185,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
国家科技支撑计划项目(2013BAI09B04)(2015BAI12B05)
江苏省临床医学中心项目(BL2012007)
