摘要
目的探讨复方牛胎肝提取物治疗乙型肝炎肝硬化患者的疗效。方法将120例乙型肝炎肝硬化患者随机分为治疗组80例和对照组40例。给予治疗组复方牛胎肝联合基础护肝治疗,对照组仅予以基础护肝治疗,疗程3个月,对比两组患者治疗前后肝功能、肝脏硬度值(LSM),以及B超检测门静脉内径、脾脏厚度、脾静脉宽度的变化。结果在3个月治疗结束时,治疗组患者血清TBIL为(33.0±2.07)μmol/L、ALT为(36.40±5.86)U/L、LSM为(10.78±1.15)Kpa,均较对照组显著下降[分别为(48.62±4.24)μmol/L、(52.60±7.3)U/L、(15.26±2.17)Kpa,P<0.05];治疗组血清ALB水平为(35.0±1.58)g/L,较对照组明显升高[(31±1.58)g/L,P<0.05];治疗组门静脉内径为(1.26±0.08)cm,脾脏厚度为(3.97±0.04)cm,脾静脉宽度为(0.87±0.02)cm,均较对照组显著降低[分别为(1.36±0.05)cm、(4.20±0.10)cm、(0.92±0.02)cm,P<0.05]。结论复方牛胎肝提取物可显著改善乙型肝炎肝硬化患者的肝功能,减轻肝纤维化程度。
Objective To investigate the effect of compound embryonic bovine liver extract in patients with hepatitis B related liver cirrhosis. Methods One hundred and twenty patients with hepatitis B induced liver cirrhosis were randomly divided into two groups,with 80 in treatment group receiving compound embryonic bovine liver extract tablets at the base of basic liver-protecting treatment and 40 in control group receiving the basic liver-protecting treatment only for 3 months. Liver function tests,liver stiffness measurement（LSM） by Fibrotouch,and portal vein diameters,spleen thickness and splenic vein width before and after treatment were compared in both groups. Results At the end of 3-month treatment,serum TBIL,ALT,and LSM values in patients in treatment group were（33.0±2.07） μmol/L,（36.40±5.86） U/L,（10.78±1.15） Kpa,respectively,significantly decreased as compared with those in the controls [（48.62±4.24） μmol/L,（52.60±7.3） U/L,（15.26±2.17） Kpa,respectively,P〈0.05 for all];serum ALB levels in patients in treatment group increased significantly compared with that in controls[（35.0±1.58） g/L vs.（31±1.58） g/L,P〈0.05];portal vein diameters,spleen thickness and splenic vein widths remarkably decreased compared with those in patients in the control group [（1.26±0.08） cm vs.（1.36±0.05）cm,（3.97±0.04） cm vs.（4.20±0.10） cm,（0.87±0.02） cm vs.（0.92±0.02） cm,P〈0.05 for all]. Conclusions Compound embryonic bovine liver extract can significantly improve the liver function and inhibit liver fibrosis in patients with hepatitis B induced liver cirrhosis.
出处
《实用肝脏病杂志》
CAS
2015年第3期262-265,共4页
Journal of Practical Hepatology
关键词
肝硬化
乙型肝炎
复方牛胎肝提取物
疗效
Liver cirrhosis Compound embryonic bovine liver extract Hepatitis B Efficacy
