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重组人脑利钠肽辅助治疗新生儿持续肺动脉高压20例

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摘要 目的评价重组人脑利钠肽(rh BNP)辅助治疗新生儿持续肺动脉高压(PPHN)的有效性和安全性。方法PPHN患儿38例,随机数字表法将患者随机分为治疗组20例,对照组18例。在常规治疗的基础上,治疗组给予冻干rh BNP 0.01~0.03μg·kg^-1·min^-1,48 h持续泵入;对照组予硫酸镁注射液20~50 mg·kg^-1·h^-1。比较两组治疗前后氧分压、二氧化碳分压、肺动脉压(PAP)、体循环收缩压(SBP)、氧合指数(OI)的变化。结果治疗48 h后,治疗组和对照组氧分压分别为(9.10±0.81),(8.21±1.00)k Pa;二氧化碳分压分别为(5.13±0.49),(6.00±0.40)k Pa,OI分别为(200.7±6.9),(162.8±3.3),均差异有统计学意义(均P〈0.05)。治疗组血气指标和OI均明显改善,PAP下降,SBP无明显下降。结论 rh BNP辅助治疗新生儿PPHN有良好疗效,可有效降低PAP,改善临床症状,且对SBP无明显影响。
出处 《医药导报》 CAS 2015年第5期626-628,共3页 Herald of Medicine
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参考文献11

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