摘要
目的探讨血清淀粉样蛋白A(SAA)和C-反应蛋白(CRP)联合检测在小儿感染性疾病鉴别诊断中的临床价值。方法选取2012年1月至2013年12月间住院患儿166例,分为细菌感染组72例,病毒感染组94例,采用免疫比浊法检测急性期和恢复期水平,并与30例健康儿童进行比较分析。结果细菌感染组SAA和CRP浓度显著高于病毒感染组和对照组,病毒感染组SAA显著高于对照组(P<0.05)。细菌感染组中重症组SAA和CRP浓度显著高于轻症组,轻症组SAA和CRP浓度显著高于对照组(P<0.05)。SAA和CRP单独检测阳性率较低,两者联合检测能提高检出率。结论 SAA和CRP联合检测在小儿感染性疾病鉴别诊断、疗效动态观察中有重要应用价值。
Objective To explore the clinical value of detecting seurm amyloid A （SAA） and C-reactive protein （CRP） in differential diagnosis of pediatric infectious disease. Methods A total of 166 children with infectious diseases hospitalized during Jan. 2012 and Dec. 2013 were selected and divided into bacterial infection group （ n = 72） and viral infection group （n = 94）, with 30 healthy children as the controls. Immunoturbidimetry method was used to detect the levels of SAA and CRP in the acute phase and recovery phase; the results were compared with the controls. Results The levels of SAA and CRP in bacterial infection group were significantly higher than those in viral infection group and the control group. The level of SAA in viral infection group was significantly higher than that in control group （ P 〈 0. 05 ）. The levels of SAA and CRP in severe subgroup of bacterial infection group were significantly higher than those in mild subgroup, and those in mild subgroup were significantly higher than in con- trol group （ P 〈 0. 05 ）. The positive rate of SAA or CRP detection alone was lower, while the joint detection im- proved the detection rate. Conclusion Joint detection of SAA and CRP has significant applicable value in differ- ential diagnosis of pediatric infectious disease and in dynamic efficacy observation.
出处
《中国微生态学杂志》
CAS
CSCD
2015年第4期429-430,433,共3页
Chinese Journal of Microecology
基金
湖北省卫生厅青年人才基金(QJX2012-32)
