摘要
目的 估算我国人群胃癌辐射致癌危险系数.方法 应用美国电离辐射效应委员会研发的日本原子弹爆炸幸存者胃癌辐射致癌危险模型,估算其辐射致癌超额相对危险和绝对危险系数.综合日本人群辐射致癌危险转移为美国人群危险的多种转移方法,确定由日本人群向我国人群危险转移模型为相乘相加混合模型（算数尺度下,相乘和相加模型权重分别为0.7和0.3）.根据我国肿瘤登记年报胃癌基线发病率,利用曲线拟合方法,估算其性别-年龄别基线发病率.综合日本人群胃癌辐射致癌危险系数及我国人群胃癌基线发病率,结合适用于我国人群的危险转移方法,估算我国人群胃癌辐射致癌危险系数.结果 估算获得我国人群胃癌辐射致癌超额相对危险系数值,男性为0.26/Sv,女性为0.64/Sv（30岁受照,60岁患癌）.受照年龄越小,患癌年龄越小此系数越大.结论 我国人群胃癌辐射致癌危险系数高于日本原子弹爆炸幸存者,二者随性别-年龄变化趋势相同.
Objective To estimate the excess relative risk coefficients of stomach cancer for Chinese population attributable to ionizing radiation.Methods The excess relative risk and excess absolute risk coefficients of stomach cancer were estimated based on Life Span Study by using risk models developed by BEIR Ⅶ committee （Biological Effect of Ionizing Radiation）.Guided by transportation methods from Life Span Study to Americans,we determined that transportation method for Chinese population includes both multiplicative and additive models with a weight of 0.7 and 0.3 respectively,on an arithmetic scale.Besides,curve fitting was used to obtain sex-age-specific stomach cancer baseline incidence based on Chinese cancer annual report.Then,Chinese excess relative risk coefficients of stomach cancer were obtained by substituting excess relative risk,excess absolute risk of Life Span Study and Chinese baseline incidence rate into risk transportation model.Results Excess relative risk coefficients of stomach cancer for Chinese population are 0.26/Sv for male and 0.64/Sv for female,whose exposure age is 30 years old and cancer age is 60 years old.Coefficients increase with decreased exposure age and cancer age.Conclusions Excess relative risk coefficients of stomach cancer for Chinese population are by larger higher than that of Life Span Study,and their sex-age tendency are similar.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2015年第4期282-286,共5页
Chinese Journal of Radiological Medicine and Protection
基金
卫生部卫生标准制（修）订项目（20130702）
教育部高等学校博士学科点专项科研基金资助项目-新教师类（20121106120041）
关键词
辐射致癌危险
人群间危险转移
癌症基线发病率
胃癌
Excess risk of radiation carcinogen
Risk transportation between populations
Baseline of cancer incidence rate
Stomach cancer
