摘要
目的探讨小视野体素内不相干运动（IVIM）MRI在宫颈癌术前分级的可行性。资料与方法收集经手术病理证实的23例宫颈癌患者,术前行MRI常规序列及IVIM序列扫描,IVIM序列包括10个b值（0-1500 s/mm^2）,根据肿瘤分化程度将患者分为高分化组（I级）10例和中低分化组（II、III级）13例。计算高分化组、中低分化组的表观扩散系数（ADC）standard值、慢速表观扩散系数D值、快速表观扩散系数D＊值和灌注分数f值,采用受试者工作特征（ROC）曲线下面积评价参数价值的准确性。结果中低分化组的ADCstandard值、D值与高分化组比较,差异有统计学意义（t=140.5、129.5,P〈0.05）;ADCstandard值、D值的曲线下面积分别为0.965和0.854,高分化组和中低分化组的敏感度和特异度分别为88.9%、100.0%和77.8%、81.8%;D＊值和f值组间差异无统计学意义（t=-0.184、1.072,P〉0.05）。结论小视野IVIM MRI技术在术前预测宫颈癌的高、中低分化程度是可行的。
PurposeTo probe into the feasibility of small field of view intravoxel incoherent motion （IVIM） MRI in the grading of cervical cancer before surgery.Materials and Methods Twenty-three patients with cervical cancer confirmed pathologically underwent preoperative conventional MRI and IVIM sequence scan [IVIM sequence included 10 b value （0-1500 s/mm^2）]. Based on postoperative pathological cell morphology the patients were divided into well differentiated group （10 cases） and moderately or poorly differentiated group （13 cases）. Then the parameters such as the ADC standard, D value, D＊ value and f value were calculated in each group according to double exponential function analysis. The data in the two groups were compared and nonparametric test to see whether they had normal distribution.Results Compared with the well differentiated group, the moderately or poorly differentiated group had statistically lower ADC standard value and D value （t=140.5 and 129.5,P〈0.05）; the area under the D value curve was 0.965 and 0.854, respectively. The sensitivity and specificity of well differentiated group and moderately or poorly differentiated group were 88.9%, 100.0% and 77.8%, 81.8%, respectively. There was no difference in either D＊ value or f value between the two groups （t=-0.184 and 1.072,P〉0.05）.Conclusion Small field of view IVIM MRI is feasible in predicting the differentiation of tumor in the preoperative grading of cervical cancer.
出处
《中国医学影像学杂志》
CSCD
北大核心
2015年第3期219-221,225,共4页
Chinese Journal of Medical Imaging
基金
邯郸市科技计划项目(1423108062-6)
关键词
宫颈肿瘤
磁共振成像
扩散加权成像
表观扩散系数
病理学
外科
Uterine cervical neoplasms
Magnetic resonance imaging
Diffusion weighted imaging
Apparent diffusion coefficient
Pathology, surgical
