摘要
目的探讨肝动脉化疗栓塞术和热灌注化疗治疗肝癌的对比情况。方法分析湖北省宜都市第一人民医院2010年9月～2014年9月收治的80例肝癌患者的临床资料，依据治疗方法不同进行分组，栓塞术组40例和热灌注术组40例。观察两组肝癌患者临床疗效评价情况、治疗前后卡氏评分情况和不良反应发生情况。结果两组肝癌患者客观有效率（47．5％比45．0％）和临床获益率（70．0％比67．5％）比较，差异无统计学意义（P〉0．05）。两组患者肝癌患者卡氏评分治疗后[（69．8±18．9）、（70．2±18．6）分]均高于治疗前[（36．7±10．5）、（35．8±11．1）分]，差异有统计学意义（P〈0．05）；治疗后组间比较，差异无统计学意义（P〉0．05）。两组肝癌患者手足皮肤反应（50．0％比45．0％）、乏力（30．0％比32．5％）、腹泻（52．5％比47．5％）、口腔炎症（30．O％比32．5％）、高血压（10．0％比7．5％）发生率比较。差异无统计学意义（P〉0．05）。结论肝动脉化疗栓塞术和热灌注化疗治疗肝癌均具有较好的临床效果，不良反应少，值得临床推广应用。
Objective To compare effect of hepatic artery chemoembolization and hot perfusion chemotherapy treating liver cancer. Methods From September 2010 to September 2014, in Yidu First People＇s Hospital, the clinical data of 80 patients with liver cancer were analyzed, according to different treatment measures, they were divided into embolization group 40 cases and thermal perfusion group 40 cases, The clinical curative effect evaluation, Carr＇s score before and after the treatment, adverse reactions of two groups were observed. Results The objective response rate （47.5% vs 45.0%） and the clinical benefit rate （70.0% vs 67.5%） of the patients with liver cancer in two groups were compared, the differences were not statistically significant （P 〉 0.05）. The Carr＇s scores of the patients with liver cancer in two groups after treatment [（69.8 ± 18.9）, （70.2 ±18.6） scores] were higher than those before treatment [（36.7± 10.5）, （35.8 ± 11.1） scores]; and these after the treatment of two groups were compared, the difference was not statistically significant （P 〉 0.05）. The occurrence rate of hand, foot and skin reaction （50.0% vs 45.0% ,）, lacking in strength （30.0% vs 32.5%）, diarrhea （52.5% vs 47.5%）, oral cavity inflammation （30.0% vs 32.5%）, high blood pressure （10.0% vs 7.5%） of patients with liver cancer in the two groups were compared, the differences were not statistically significant （P 〉 0.05）. Conclusion Both of hepatic artery chemoembolization and hot perfusion chemotherapy treating liver cancer are obviously clinical curative effect, less adverse reaction, which are worthy to be used.
出处
《中国医药导报》
CAS
2015年第14期94-97,共4页
China Medical Herald
关键词
肝动脉化疗栓塞术
热灌注化疗
肝癌
Hepatic artery chemoembolization
Hot perfusion chemotherapy
Liver cancer
