摘要
目的：研究精准肝切除术治疗原发性肝癌对血清恶性生物学指标的影响。方法：将2013年5月~2014年8月期间我院收治的90例原发性肝癌患者纳入研究,随机分为两组,观察组患者接受精准肝切除术,对照组患者接受不规则肝切除术,比较两组患者血清中肝癌活力指标、免疫分子含量以及信号通路分子含量。结果：（1）肝癌活力指标：观察组患者血清中胸苷激酶（TK1）、Polo样激酶1（Polo-like kinase 1,Plk1）、Bcl-2、Livin、Xiap、HIF-1α含量低于对照组（P〈0.05）;（2）免疫分子：观察组患者血清中CD44、CD90、CD133、CD147含量低于对照组（P〈0.05）;（3）信号通路分子：观察组患者血清中SHH、Notch1、Jagged1、JAK、STAT1、STAT3、STAT5含量低于对照组（P〈0.05）。结论：精准肝切除术有助于减小手术创伤,避免肝癌活力分子、免疫分子以及恶性生物学信号分子释放入血,是治疗原发性肝癌的理想方法。
Objective.. To study the effect of precise hepatectomy on serum malignant biological index of primary carci- noma. Method： A total of 90 cases of primary carcinoma in our hospital from 2013 August to 2014 May were enrolled and ran- domly divided into two groups. Patients in observation group received precise hepatectomy, control group received irregular hepatectomy. Then hepatocellular carcinoma vigor index, immune molecule content and signal pathway content were com- pared. Results： Serum TK-1, Plk-1, Bcl-2, Livin, Xiap, HIF-1α contents of observation group were significantly lower than those of control group（P〈0.05）. Serum CD44, CD90, CD133, CD147 contents of observation group were significantly lower than those of control group（P〈0.05）. SHH, Notch1, Jagged1, JAK, STAT1, STAT3, STAT5 contents of observation group were significantly lower than those of control group（P〈0.05）. Conclusion： Precise hepatectomy is helpful to reduce surgical trauma, avoid HCC vigor molecular, immune molecules and malignant biological signal molecules released into blood; it＇ s an ideal method in treating primary hepatocellula cancer.
出处
《海南医学院学报》
CAS
2015年第6期822-824,828,共4页
Journal of Hainan Medical University
基金
湖北省荆州市科技局基金项目(201283723)~~
关键词
原发性肝癌
精准肝切除术
恶性生物学
信号通路
Primary hepatocellula cancer
Precise hepatectomy
Malignant biology
Signal pathway
