摘要
为探讨慢性乙型肝炎 (下称慢乙肝 )、乙肝肝硬化 (下称肝硬化 )与骨代谢的关系 ,分别对 32例慢乙肝、32例肝硬化和 31例对照组患者进行了骨钙素 (BGP)、甲状旁腺激素 M(PTHM)、血钙、血磷及尺桡骨骨密度(BMD)检测。结果显示 ,肝硬化组血清 BGP水平较肝炎组和对照组明显降低 (P<0 .0 5、<0 .0 1) ,血清 PTHM水平较肝炎组及对照组升高 (P<0 .0 5、<0 .0 5 ) ;两肝病组血钙水平较对照组明显下降 (P均 <0 .0 0 1) ,BMD较对照组降低 (P<0 .0 0 1、<0 .0 1) ;肝硬化组和肝炎组 BGP均与 BMD呈正相关。提示慢性病毒性肝病可出现调钙激素异常变化 ,且其骨质疏松随肝病加重而呈加重趋势。
To investigate the correlation between chronic hepatitis B(CHB),HBV related liver cirrhosis(LC) and bone metabolism,serum osteocalcin,parathyroidin,calcium,phosphorus and bone mineral density(BMD) were examined respectively in 32 cases of CHB,32 cases of LC and 31 cases of the controls.The results showed that serum levels of BGP in LC were much lower than CHB and the controls(P<0.05?<0.01). The elevated levels of parathyroidin were observed in patients with LC and CHB,especially in LC.The serum levels of calcium in the patients were remarkably lower than the controls,so did BMD.The positive relationship was found between osteocalcin and BMD in patients with LC and CHB.This suggests that pathological changes of osteocalcin,parathyroidin are closely related to the degree of liver injuries.With progression of liver disease,hepatic bone disease characterized with osteoporosis become worse.
出处
《山东医药》
CAS
北大核心
2002年第13期1-2,共2页
Shandong Medical Journal
