摘要
目的分析幽门螺杆菌(HP)感染与血清糖类抗原724(CA724)的相关性。方法选取229例HP感染的消化内科住院患者作为观察组,并根据诊断结果分为不同的疾病组;另选取100例同期体检健康者作为健康对照组。采用13碳(13C)尿素呼气试验检测所有受试者的HP,采用化学发光免疫分析法检测血清CA724水平,并进行比较分析。结果 HP感染的各疾病组HP值和血清CA724水平均高于健康对照组,差异均有统计学意义(P<0.05)。HP值以十二指肠溃疡组最高,其余各疾病组的HP值两两比较差异均无统计学意义(P>0.05);血清CA724水平以胃癌组最高,其余各疾病组血清CA724水平两两比较差异均无统计学意义(P>0.05)。所有疾病组患者HP值与血清CA724水平呈正相关(0.331,P<0.01)。结论 HP感染与血清CA724水平具有相关性,其中胃癌组血清CA724水平增高明显,其他各疾病组呈低水平增高;动态观察伴有HP感染的上消化道疾病患者血清CA724水平,有助于早期诊断与预防上消化道病变的进一步加重,可为临床早期发现胃癌等上消化道病变提供有效的诊断依据。
Objective To investigate the correlation of Helicobacter pylori （HP） infection and serum carbohydrate antigen 724 （CA724） level .Methods 229 patients with HP infection hospitalized in gastroenterology department were enrolled in the observation group ,and patients were divided into different disease group according to the results of diagnosis .Other 100 healthy people , conducted physical examination ,were enrolled in the healthy control group .The HP infection was detected by 13C‐urea breath test and the serum CA724 level was detected by chemiluminescent immunoassay .Results The HP value and serum CA724 levels in each disease group were higher than those in the healthy control group ,with significant differences（P〈0 .05） .The HP value was highest in the duodenal group ,and there was no statistical differences between each disease groups （P〉0 .05） ,except the duodenal group .The serum CA724 level was highest in the gastric cancer group ,there was no statistical differences between each disease groups（P〉0 .05） ,except the gastric cancer group .The serum CA724 level was positively correlated with HP value in patients with HP infection（r=0 .331 ,P〈0 .01） .Conclusion HP infection may correlate with serum CA724 level .The serum CA724 level in the gastric cancer group increased more significantly ,in other disease groups increased steadily .Dynamic observation of serum CA724 level in patients with upper gastrointestinal tract disease associated with HP infection could be helpful for early diagnosis and pre‐vention of aggravation of lesions ,and could provide effective diagnosis basis for early detection of upper gastrointestinal tract lesions ,such as gastric cancer .
出处
《国际检验医学杂志》
CAS
2015年第8期1084-1085,1087,共3页
International Journal of Laboratory Medicine
关键词
幽门螺杆菌
感染
糖类抗原724
相关性
Helicobacter pylori
infection
carbohydrate antigen 724
correlation
