摘要
目的探讨降钙素原(procalcitonin,PCT)在糖尿病足感染中的变化及临床意义。方法选取84例糖尿病足感染(diabetic foot,DF)患者为DF组,62例单纯糖尿病(diabetes mellitus,DM)患者为DM组。比较两组患者血清PCT、超敏C反应蛋白(hs-CRP)、空腹血糖(GLU)、白细胞(WBC)计数及中性粒细胞百分比。结果治疗前,DM组血清PCT、hs-CRP、GLU、WBC计数及中心粒细胞百分比分别为(0.4±0.1)μg/L、(9.8±3.2)mg/L、(7.6±2.1)mmol/L、(8.2±1.2)×109/L、(62.4±3.1)%,DF组分别为(9.6±2.9)μg/L、(23.2±7.1)mg/L、(9.3±2.2)mmol/L、(11.5±1.8)×109/L、(76.2±4.9)%,两组各指标比较差异均有统计学意义(P<0.05)。DF组不同Wagner分级患者间GLU、PCT、hs-CRP、WBC及中性粒细胞百分比均随着级别升高而升高;Wagner分级4、5级患者hs-CRP水平显著高于1级患者(P<0.05);Wagner分级2、3、4、5级患者PCT水平均显著高于1级患者(P<0.05);DF组间GLU、WBC及中性粒细胞比较差异无统计学意义(P>0.05)。DF组不同Wagner分级患者治疗后PCT水平均显著降低,与治疗前比较差异有统计学意义(P<0.05)。结论糖尿病足感染(DF)患者血清PCT显著升高,监测血清PCT变化可作为判断DF合并感染严重程度及转归的可靠指标。
Objective To evaluate the change and clinical significance of serum procalcitonin （PCT）in pa-tients with diabetic foot infections.Methods 84 cases with diabetic foot infections were selected as DF group;and the 62 cases with pure diabetes mellitus as DM group.The serum PCT,high sensitivity C-reac-tive protein（hs-CRP）,fasting blood-glucose,neutrophile granulocyte and white blood cell count were compared between the two groups.Results Before treatment,the PCT,hs-CRP,fasting blood-glucose, neutrophile granulocyte and white blood cell count of DM group respectively were（0.4±0.1）μg/L,（9.8± 3.2）mg/L,（7.6±2.1）mmol/L,（8.2± 1.2）· 10 9/L and（62.4±3.1）%,those of DF group respectively were （9.6±2.9）μg/L,（23.2±7.1）mg/L,（9.3±2.2）mmol/L,（11.5±1.8）·10 9/L and（76.2±4.9）%, the differences between the two groups showed statistically significant （P 〉 0.05）.The PCT,hs-CRP, fasting blood-glucose,neutrophile granulocyte and white blood cell count of DF group were rose along with the Wagner grades increased.The hs-CRP level of patients with wagner grade 4 and grade 5 were was sig-nificantly higher than that of grade 1 （P 〉0.05）.The PCT level of patients with wagner grade 2,grade 3, grade 4 and grade 5 were was significantly higher than that of grade 1 （P 〉0.05）.Fasting blood-glucose, neutrophile granulocyte and white blood cell count between DF group comparison difference had no statis-tical significance （P ＆gt;0.05）.After treatment,the PCT level of DF group between different Wagner classi-fying patients were significantly lower than before treatment,the differences had statistically significant （P 〉0.05）.Conclusion The serum PCT is markedly elevated in the diabetic foot infections patients,mo-nitor changes of serum PCT can be used as an reliability index for the the severity and outcome of judg-ment diabetic foot infection.
出处
《新疆医科大学学报》
CAS
2015年第4期463-465,470,共4页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区自然科学基金(2014211C047)
关键词
糖尿病足
感染
降钙素原
Diabetic foot
Infection
Procalcitonin
