摘要
大鼠局灶性脑缺血后２４ｈ血浆ＥＴ－１含量显著升高，ｔ－ＰＡ浓度显著降低，而ＰＡＩ－１无变化。乌龙丹６ｇ／ｋｇ对ＥＴ升高有显著的对抗作用，而１．５ｇ／ｋｇ可使ｔ－ＰＡ浓度维持正常水平或增高。
Wulong Dan was a prescription being made into preparation in acoordance our clinical experience. In this paper, we reported the pharmacological action and mechanism of Wulong Dan on a model of focal cerebal ischemic in the rat. The results showed that Wulong Dan has a significant effect of antagonism to increase of endothilin-1(ET-1) concentration and decrease of tissue-type plasminogen activator(t-PA) activity in the plasma of rats which middle cerebral artery was occluded for 24 hours. It can keep normal vascular endocrine funtion and antagonize the damage of brain ischemia in the rats.
出处
《中药药理与临床》
CAS
CSCD
1997年第2期28-31,共4页
Pharmacology and Clinics of Chinese Materia Medica
